BACKGROUND AND OBJECTIVE This study sought to evaluate anterior capsulorhexis opening (ACO) reductions after surgery for a subluxated lens. Significant reduction of an ACO supports direct zonular involvement (capsular factors excluded by use of capsular tension rings [CTRs] and modern intraocular lens [IOLs]), and these findings question the long-term efficacy of subluxated lens surgery by mean...

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The effect of in vivo x-irradiation on rabbit lens permeability was studied by the Rb runout method. At 24 hours following x-irradiation of the lens the rate of Rb runout was found to be increased and reached a maximum at one week. Over the subsequent 2 weeks the rate of Rb runout decreased, although still remaining above normal. The increase in lens permeability preceded the appearance of lens...

PURPOSE Signal transduction pathways influence lens growth, but little is known about the role(s) of the class 1A phosphoinositide 3-kinases (PI3Ks). To further investigate how signaling regulates lens growth, we generated and characterized mice in which the p110α and p110β catalytic subunits of PI3K were conditionally deleted in the mouse lens. METHODS Floxed alleles of the catalytic subunit...

BACKGROUND People who are street involved such as those experiencing homelessness and drug use face multiple inequities in health and access to health care. Morbidity and mortality are significantly increased among those who are street involved. Incorporation of a harm reduction philosophy in health care has the potential to shift the moral context of health care delivery and enhance access to ...

AIMS To analyse long term effects on the lens of radium irradiation during infancy. METHODS An infant cohort (n = 20, median age 6 months) treated for skin haemangioma with one or two radium-226 needles located at or within the orbital rim was examined 30 to 45 years after gamma radiation. Detailed information about the treatment procedure was available for all cases. Subcapsular opacities we...

background: radiotherapy plays an important role in the management of most malignant and many benign primary central nervous system (cns) tumors. radiotherapy affects both tumor cells and uninvolved normal cells; so, it is important to estimate absorbed dose to organs at risk in this kind of treatment. the aim of this study was to determine the absorbed dose to chiasma, lens, optic nerve, retin...

PURPOSE The development of posterior capsule contraction following cataract surgery is caused by the activity of residual lens epithelial cells. Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes, which are essential for cell migration and cell mediated contraction following wound healing. The authors investigated whether inhibiting MMP activity can reduce lens epithelial cell ...

Oxidized and reduced proteins were prepared from the ocular lenses of sheep, swine, chicken and fish (pike). The proteins were prepared under conditions designed to avoid denaturation and to produce relatively pure compounds. Serologic studies revealed that species specificity is demonstrable in the proteins from chicken and fish lenses, but in the more closely related species (swine and sheep)...