Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial process. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contr...

Millions are rendered blind or exhibit visual impairment due to pathologies of the lens of the eye. Lens research therefore addresses the direct need to gain insights into the cellular and molecular basis of disease, but, moreover, serves as a valuable experimental system to answer fundamental biological questions. This themed issue showcases the scientific knowledge of the processes involved i...

BACKGROUND Oxidative stress has been implicated in cataractogenesis. Long-term intake of antioxidants may offer protection against cataract. OBJECTIVE We investigated relations between antioxidant nutrient intakes measured at baseline and the 10-y incidence of age-related cataract. DESIGN During 1992-1994, 3654 persons aged >or=49 y attended baseline examinations of the Blue Mountains Eye S...

PURPOSE The CRYAAN101D transgenic mouse model expressing deamidated αA-crystallin (deamidation at N101 position to D) develops cortical cataract at the age of 7 to 9 months. The present study was carried out to explore the molecular mechanism that leads to the development of cortical opacity in CRYAAN101D lenses. METHODS RNA sequence analysis was carried out on 2- and 4-month-old αA-N101D and...

E2012, a gamma secretase modulator without affecting Notch processing, aimed at Alzheimer's disease by reduction of amyloid β-42, induced cataract following repeated doses in the rat. Cataract appeared first at week 10-11 of treatment as a posterior subcapsular area with granular/punctate opaque or shiny dots along the suture line, characterized histologically as lenticular fiber degeneration, ...

Aim of our paper is to present a case of painless Acanthamoeba keratitis in a soft contact lens wearer. A 17-year-old male, highly myopic, prolonged soft contact lens wearer, presented to us with painless red watery right eye having remarkably diminished vision. Last six weeks he was treated elsewhere for the microbial keratitis with no improvement. No pain was reported and on the direct questi...

A chemical mutagenesis to identify zebrafish eye morphological mutants was performed by screening F(3) larvae at 5 and 7 days post-fertilization (dpf) for changes in eye or pupil size. Based on histological analysis, four different phenotypic classes were obtained. The two Class I and three Class II mutants are all characterized by small eyes and exhibit defects in early retinal development or ...

Methods: This was a cohort study nested within a randomized clinical trial. There were 235 participants with glaucoma who had a single previous trabeculectomy augmented with either intraoperative 5-fluorouracil or placebo. Cataract surgery with intraocular lens implantation was performed on participants judged to have significant lens opacity. Cox regression was performed to evaluate the effect...

Kador's paper would have been much more complete had it mentioned some current inhibitors of sorbitol formation. In addition to the article on sugar-induced opacities, Human Cataract Formation contains thirteen other research papers. The subjects range from calcium and the physiology of cataracts to cytoskeletal proteins of the aging human lens. Most of the work in the symposium is concise, luc...

It has been noted that patients suffering from long-standing rheumatoid arthritis often display a characteristic corneal lesion. This consists of a partial opacity of the periphery of the cornea involving part or all of its circumference. The cornea in this area is thinned, usually by about a third of its normal thickness and has a well-demarcated central edge. It is minimally vascularized by s...