نتایج جستجو برای: lentiviral vectors

تعداد نتایج: 71689  

2014
Ulrike Mock Kristoffer Riecken Belinda Berdien Waseem Qasim Emma Chan Toni Cathomen Boris Fehse

TAL-effector nucleases (TALENs) are attractive tools for sequence-specific genome modifications, but their delivery still remains problematic. It is well known that the presence of multiple sequence repeats in TALEN genes hampers the use of lentiviral vectors. We report that lentiviral vectors readily package full-length vector mRNAs encoding TALENs, but recombination during reverse transcripti...

Journal: :Cell & gene therapy insights 2021

Gene therapy is no longer an experimental approach. We are now witnessing the advent of genes as medicinal products, based on stable expression therapeutic genes. Laboratory-borne viruses, also known viral vectors, can efficiently deliver to cells they infect, with lentiviral vectors (LVVs) one most widely used. This article will review existing lentivirus-manufacturing tech...

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