نتایج جستجو برای: lesch
تعداد نتایج: 4630 فیلتر نتایج به سال:
MOTIVATION Mathematical modeling and optimization have been used for detecting enzyme targets in human metabolic disorders. Such optimal drug design methods are generally differentiated as two stages, identification and decision-making, to find optimal targets. We developed a unified method named fuzzy equal metabolic adjustment to formulate an optimal enzyme target design problem for drug disc...
We define a new topology, weaker than the gap topology, on the space of selfadjoint unbounded operators on a separable Hilbert space. We show that the subspace of selfadjoint Fredholm operators represents the functor K from the category of compact spaces to the category of abelian groups and prove a similar result for K. We define the spectral flow of a continuous path of selfadjoint Fredholm o...
5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve t...
Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcr...
Friedrich M. Wurst, Boris Tabakoff, Christer Alling, Steina Aradottir, Gerhard A. Wiesbeck, Franz Müller-Spahn, Fritz Pragst, Bankole Johnson, Marty Javors, Nassima Ait-Daoud, Gregory E. Skipper, Claudia Spies, Yvonne Nachbar, Otto Lesch, Katrin Ramskogler, Susanne Hartmann, Manfred Wolfersdorf, Sebastian Dresen, Wolfgang Weinmann, Lisa Hines, Alan Kaiser, Ru-Band Lu, Huei-Chen Ko, San-Yuan Hua...
Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompa...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید