The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. We have investigated whether the generation of oxidative free radical species by aniline and/ or its metabolites may be responsible for its recombin...

The effects of polychlorinated dibenzofurans (PCDFs), trace toxic contaminants of commercial polychlorinated biphenyl preparations (PCBs), on the induction of hepatic drug-metabolizing enzymes were studied in the rat. PCDFs were about a thousand times more potent than PCBs (Kanechlor-500) as inducers of cytochrome P-450. Rats given 10 microgram/kg of PCDFs intraperitoneally for 3 days showed si...

Alterations in the normal subcellular metal distribution of rat liver and lung have been produced by the acute administration of phénobarbital, carbon tetrachloride, and intratracheal 3,4-benzpyrene. Following the isolation of the various subcellular fractions by a standard technique, the metal composition of the subfractions was determined by atomic absorption spectrophotometry and expressed ...

The interactions of aniline with soil at an industrial spill site were investigated. Sorption of aniline to the soil was observed to occur through a two-step mechanism. The first step was an ion exchange process with the protonated amine serving as an organic cation. This step was influenced by solution pH and ionic composition. The second step was covalent bonding most likely with quinone moie...

Enhancement of aniline hydroxylation by Habu snake venom was studied in vitro. The fraction which was isolated from Habu venom through column chromatography caused the enhancement of aniline hydroxylation of hepatic microsomes obtained from untreated rats. This fraction was heat stable and free from phospholipase activity. Enhancement of aniline hydroxylation was not clear in crude Habu venom o...

Background: Phenylketonuria as the most common genetic metabolic disorder is the result of disruption of the phenylalanine hydroxylase gene. This study was carried out to explore the phenylalanine hydroxylase gene mutation status of Iranian phenylketonuria patients.    Methods: Blood samples were collected from 30 patients, and hot spot areas of the phenylalanine hydroxylase gene, in...

Electrical sensitivity of a beryllium oxide nanotube (BeONT) was examined toward aniline (C6H5 NH2) molecule by using Density Functional Theory (DFT) calculations at the B3LYP/6-31G (d) level, and it was found that the adsorption energy (Ead) of aniline on the pristine nanotubes is about -19.06kcal/mol. However, when nanotube has been doped by P a...

Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles is still a biochemical riddle. The present study aims at understanding the specific role of aniline (as precursor or stimulator) in the producti...

Infrared photodissociation spectra of aniline+–M (M = thiophene, furan and phenol) are measured in the 2700–3700 cm–1 region and analyzed by density functional theory calculations. Only a structure with a π-type hydrogen bond is found for aniline+–thiophene. Two structural isomers are identified for aniline+–furan and aniline+–phenol, which have either a π-type or a σ-type hydrogen bond, where ...