in healthy volunteers. Levocetirizine reduces plasmatic level of IL-6 (1.19 versus 1.006, P 1⁄4 0.0097) and IL-8 (8.90 versus 6.90, P 1⁄4 0.0003) after 4 weeks treatment, while Desloratadine has influence only IL-6 level (1.68 versus 1.36, P 1⁄4 0.0038). The intergroup analysis revealed no significant difference between these 2 drugs regarding IL-6 (P 1⁄4 0.36) and IL-8 (P 1⁄4 0.25). Conclusion...

in healthy volunteers. Levocetirizine reduces plasmatic level of IL-6 (1.19 versus 1.006, P 1⁄4 0.0097) and IL-8 (8.90 versus 6.90, P 1⁄4 0.0003) after 4 weeks treatment, while Desloratadine has influence only IL-6 level (1.68 versus 1.36, P 1⁄4 0.0038). The intergroup analysis revealed no significant difference between these 2 drugs regarding IL-6 (P 1⁄4 0.36) and IL-8 (P 1⁄4 0.25). Conclusion...

A rapid, accurate RP Levocetirizine and phenylephrine separation was achieved on column Luna 5u C18 (20mm X 4mm) using mobile phase of methanol: Pot. Dihydrogen Phosphate Buffer (pH 6.0), (70:30) .The UV detection was performed at 251nm with flow rate of 1.0 mL Phenylephrine hydrochloride was found to be 8.42 min and 2.70 min with mean recovery 100.64 & 100.40% respectively. The proposed method...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

There is considerable evidence that several novel H1 antihistamines possess anti-allergic/ anti-inflammatory properties, through inhibition of leukocyte activation. Levocetirizin and other H1 antihistamines are considered central to the treatment of atopic dermatitis (AD) associated pruritis; however there is a lack of studies of possible anti-inflammatory effect of these drugs in children with...

The evaluation of quality of life (QoL) and its modification through therapeutic interventions has become a prioritary concern in recent years and a requirement on the part of regulatory agencies for the authorization of new drugs. In clinical studies of allergic disorders, particularly allergic rhinitis and urticaria, different types of generic questionnaires have been used - especially diseas...

BACKGROUND The H1-antihistamine cetirizine, a piperazine derivative widely used in daily practice, is rarely the cause of cutaneous drug reaction. Nevertheless, four cases of fixed drug eruption (FDE) as a result of this drug have been described recently. We present the case of a 45-year-old woman with a multilocalized FDE following oral intake of cetirizine for allergic rhinitis. METHODS Pat...

This article reviews the molecular biology of the interaction of histamine with its H1-receptor and describes the concept that H1-antihistamines are not receptor antagonists but are inverse agonists i.e. they produce the opposite effect on the receptor to histamine. It then discourages the use of first-generation H1-antihistamines in clinical practice today for two main reasons. First, they are...