The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical evidenced, untreated hypothyroidism. Significant effects between the untreated hypothyroid group...

we reported a 35 year old breast cancer patient who was referred to our nuclear medicine department for sentinel node mapping. she was planned to undergo mastectomy and lymphatic mapping. a dose of tc-99m phytate was injection in the peri-areolar region in an intra-dermal fashion. two hours post-injection no sentinel node was visible in the axilla. due to a high liver uptake, inadvertent intra-...

Thyroiditis is a general term that encompasses several clinical disorders characterized by inflammation of the thyroid gland. The most common is Hashimoto thyroiditis; patients typically present with a nontender goiter, hypothyroidism, and an elevated thyroid peroxidase antibody level. Treatment with levothyroxine ameliorates the hypothyroidism and may reduce goiter size. Postpartum thyroiditis...

The literature suggests that patients with bipolar disorder, particularly females, have greater vulnerability to rapid cycling features. Levothyroxine therapy might be potentially useful to attenuate mood instability in this patient group. In contrast, reports on male patients remain limited and controversial. Herein, we report a 32-year-old male patient who had bipolar 1 disorder for 12 years ...

The influence of hypothyroidism on haemostasis is an active research area. Not only bleeding tendency but also hypercoagulable states have been reported in hypothyroid patients. Decreased and increased fibrinolytic activity in hypothyroid patients has been shown in several studies. Thrombin activatable fibrinolysis inhibitor (TAFI) is an inhibitor of fibrinolysis, which has been recently isolat...

BACKGROUND While few hypothyroid patients require more than the expected weight-related dose of levothyroxine, the underlying causes of larger-than-expected dosing requirements have not been studied in a single cohort. Our aim was to determine and quantify the multiple factors contributing to high-dose levothyroxine requirements in a cohort of patients with hypothyroidism. METHODS The Grampia...

introduction struma ovarii is an ovarian teratoma, represented in more than 50% by thyroid tissue. five percent of struma ovarii cases have been proven to be malignant and, as in the thyroid gland, papillary thyroid carcinoma is the most common histotype arising in struma ovarii. because of the unusual occurrence of this tumor, its management and follow-up after pelvic surgery is still controve...

BACKGROUND Thyroid autoimmunity has been increasingly reported to be associated with chronic urticaria (CU), and the possible clinical benefit of thyroid hormone or anti-thyroid drugs in some CU patients with autoimmune thyroid disease has been studied. However, the effect of thyroid hormone or anti-thyroid drugs on clinical symptoms of CU remains unclear. OBJECTIVE We investigated the clinic...

six to 8 weeks after the start of levothyroxine therapy you should reexamine patients and measure their serum thyroidstimulating hormone (TsH) (strength of recommendation [sor]: c, common practice and expert opinion). If thyroid function is normal at that time, examine the patient and measure serum TsH again in 4 to 6 months because clearance of levothyroxine increases in the euthyroid (normal)...