In this issue of the Netherlands Heart Journal, van der Linde et al. describe a novel Dutch founder mutation (MYH7p.Asn1918Lys) in MYH7, the gene encoding myosin heavy chain 7, leading to cardiomyopathy and congenital heart defects [1]. Van der Linde et al. showed that the MYH7p.Asn1918Lys mutation resulted in predominantly dilated cardiomyopathy (DCM) but was also present in patients suffering...

This review celebrates the generous gift by Ronald and Maxine Linde for remodeling of Caltech mathematics department author is very grateful to editors this volume invitation contribute. We attempt survey recent results open problems connected Lieb–Thirring inequalities. In view several excellent existing reviews [132, 17, 113, 91, 108] as well highly recommended textbooks [134, 136], we someti...

We study the possibility of using the D-term associated to an anomalous U(1) for the uplifting of AdS vacua (to dS or Minkowski vacua) in effective supergravities arising from string theories, particularly in the type IIB context put forward by Kachru, Kallosh, Linde and Trivedi (KKLT). We find a gauge invariant formulation of such a scenario (avoiding previous inconsistencies), where the anoma...

We study SUSY phenomenology of the KKLT (Kachru-Kallosh-Linde-Trivedi) scenario of string theory compactifications with fluxes. This setup leads to a specific pattern of soft masses and distinct phenomenological properties. In particular, it avoids the cosmological gravitino/moduli problems. Remarkably, the model allows for the correct abundance of SUSY dark matter consistently with all experim...

This paper reviews and discusses the debate over the effectiveness of environmental regulation in promoting industrial Technological Environmental Innovation (TEI). Using the innovation-friendly regulatory principles adapted from Porter and van der Linde (1995a, 1995b), this paper demonstrates how properly designed and implemented environmental regulation (TEI promoting regulation) has played a...

chronisation and implantable cardioverter defibrillation in advanced chronic heart failure: the Miracle ICD trial. JAMA 2003;289:2685–2694. 25. van Veldhuisen DJ, Maass AH, Priori SG, Stolt P, van Gelder IC, Dickstein K, Swedberg K. Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes f...

We introduce inverted stippling , a method to mimic an inversion technique used by artists when performing stippling. To this end, we extend Linde-Buzo-Gray (LBG) multi-class LBG (MLBG) with multiple layers. MLBG couples the layers stochastically optimize for per-layer and overall blue-noise properties. propose stipple-based filling generate solid color backgrounds inverting areas. Our experime...