Previous studies on adaptive behaviour in single-celled organisms have given hints to the origin of their memorizing capacity. Here we report evidence that a protozoan ciliate Tetrahymena has the capacity to learn the shape and size of its swimming space. Cells confined in a small water droplet for a short period were found to recapitulate circular swimming trajectories upon release. The diamet...

The antigenic phenotype of human synovial lining cells in normal and hyperplastic synovium intima was determined with a panel of monoclonal antibodies directed against a large number of well defined myeloid (macrophage/granulocyte associated) antigens. Synovial lining cells express numerous macrophage associated antigens, including CD11b (CR3), CD13, CD14, CD16 (FcRIII), CD18, CD32 (FcRII), CD4...

Escherichia coli lactose permease (LacY) transports sugar across the inner membrane of the bacterium using the proton motive force to accumulate sugar in the cytosol. We have probed lactose conduction across LacY using steered molecular dynamics, permitting us to follow molecular and energetic details of lactose interaction with the lumen of LacY during its permeation. Lactose induces a widenin...

OBJECTIVE To examine use of the paramedian forehead flap for intranasal lining. METHODS The medical records and photographs were reviewed for patients who underwent a nasal reconstruction involving a paramedian forehead flap used for internal lining. RESULTS Three patients underwent this procedure. In all patients, the flap provided excellent intranasal lining. External incisions were accep...

A comparative analysis of cavities enclosed in a tertiary structure of proteins and interfaces formed by the interaction of two protein subunits in obligate and non-obligate categories (represented by homodimeric molecules and heterocomplexes, respectively) is presented. The total volume of cavities increases with the size of the protein (or the interface), though the exact relationship may var...

Recent years have seen enormous progress in understanding the pathogenesis of rheumatoid arthritis (RA), an autoimmunological disorder that primarily affects the joints and leads to their progressive destruction. Advances in molecular biology techniques such as the use of gene transfer and gene silencing technology, the utilization of novel animal models of destructive arthritis–particularly in...

In this work, we tried to automatically optimize the cost of the concrete segmental lining used as a support system in the case study of Mashhad Urban Railway Line 2 located in NE Iran. Two meta-heuristic optimization methods including particle swarm optimization (PSO) and imperialist competitive algorithm (ICA) were presented. The penalty function was used for unfeasible solutions, and the seg...