Objective(s)Marfan syndrome (MFS) is a severe connective tissue disorder withan autosomal dominant inheritance pattern. Early diagnosis is critical in MFS. Because of the large size of fibrillin-1 gene (FBN1), the uniqueness of mutations, and the absence of genotype-to-phenotype correlations linkage analysis can be very helpful for early diagnosis of MFS. In this study, eight polymorphic marker...

background: indigenous chickens could serve as precious genetic resources that should be considered in conservation and breeding programs. the major histocompatibility complex (mhc) has a strong association to disease resistance/susceptibility, production and reproduction traits in chicken. therefore, identifying its polymorphism in populations under selective breeding could be used for selecti...

Multilocus calculations, using all available information on all pedigree members, are important for linkage analysis. Exact calculation methods in linkage analysis are limited in either the number of loci or the number of pedigree members they can handle. In this article, we propose a Monte Carlo method for linkage analysis based on sequential imputation. Unlike exact methods, sequential imputa...

We have developed a new system for assistance of linkage analysis using the Java language and the HORB, which is an object broker for the Java language. This system includes an automatic correction of allele types, display of alleles transmission in families, normal distribution test of traits data. Introduction We are currently mapping the porcine genetic markers for linkage analysis to elucid...

Although the title of this lecture is “linkage analysis” it is going to be mostly about computing probabilities. Linkage analysis can be performed for a variety of species. We will concentrate on the case where the individuals in the pedigree are humans. Human pedigrees present some unique problems in that the data is often incomplete. In particular some individuals may be unobserved, or the tr...

Objective: This article presents an application of cluster analysis for social sciences researches especially those studies that have an interview as part of their data collection. This application is more suitable for sequential mixed method researchers who use quantitative data to frame subsequent qualitative subsamples for conducting interviews.  Methods: In more detail, the algorithm (i....