Submit Manuscript | http://medcraveonline.com Abbreviations: SLN: Solid Lipid Nanoparticles; PQ-SLNs: PQLoaded Solid Lipid Nanoparticles; o/w: Oil-in-Water; SA: Stearic Acid; PVA: Polyvinyl Alcohol; EtOAc: Ethyl Acetate; w/o: Waterin-Oil; PDI: Poly Dispersity Index; DLS: Dynamic Light Scattering; FD: Freeze Drying; HEPES: N-2-Hydroxyethylpiperazine-N-2Ethanesulfonic Acid; NP: Nanoformulated Pri...

This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases-epilepsy, Parkinson's disease, and Alzheimer's disease-selecte...

Extra-large nanochannel formation in the internal structure of cationic cubosome nanoparticles results from the interplay between charge repulsion and steric stabilization of the lipid membrane interfaces and is evidenced by cryogenic transmission electron microscopy (Cryo-TEM) and synchrotron radiation small-angle X-ray scattering (SAXS). The swollen cubic symmetry of the lipid nanoparticles e...

The enhancement in cancer chemotherapy through incorporation into solid lipid nanoparticles (SLN) drug delivery system carries a lot of potential. Improving tumor diffusivity, improvement of body distribution, enhancing cellular uptake and inhibiting multidrug resistance mechanism are the main attributes. The availability of variety of methods of preparation with scale up possibility and the hi...

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. The griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, by altering the high pressure homogenisation (HPH) parameters, screening on palm-based lipids and Tween series surfactants and selection of lipid to surfactant ratios. A HPLC method has be...

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid head groups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negativel...

INTRODUCTION Nanoparticles are rapidly developing as drug carriers because of their size-dependent properties. Lipid nanoparticles (LNPs) are widely employed in drug delivery because of the biocompatibility of the lipid matrix. AREAS COVERED Many different types of LNPs have been engineered in the last 20 years, the most important being solid lipid nanoparticles (SLNs), nanostrucured lipid ca...

Nanorattles made of hollow polymer nanocapsules with entrapped silver nanoparticles were synthesized in one step by using lipid vesicles as templates. Free radical photoinitiator facilitated both polymerization within the bilayer and formation of metal nanoparticles in the aqueous core.

Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, ...