BACKGROUND & AIMS The diagnosis of non-alcoholic steatohepatitis and fibrosis staging are central to non-alcoholic fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment of non-alcoholic steatohepatitis and fibrosis using histology as standard in non-alcoholic fatty liver disease. METHODS Seventy-one patients with suspected non-alcoholic fatty liver ...

Background: Transient Elastography (TE) is a noninvasive, reproducible tool to assess liver stiffness. Previous systemic review showed that liver stiffness measured by TE has high accuracy to detect histological liver fibrosis. However, few studies are looking at this relationship in patients with chronic hepatitis B (CHB). We aimed to assess the correlation between liver stiffness and liver fi...

Without downgrading the histological assessment of liver fibrosis, efforts are being made to develop accurate and reliable non-invasive indices as alternatives to liver biopsy. Previously proposed panels of liver fibrosis usually include 2 to 7 blood markers. The majority of publications were concerned with liver fibrosis among patients with chronic hepatitis C (CHC). However, few studies have ...

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the leading causes of hepatic fibrosis liver-related mortality worldwide, despite efficient hepatitis B C antiviral therapies that have dramatically lowered load. Although significant efforts been exerted to understand molecular basis pathogenesis, there currently few therapeutic alternatives available for NAFL...

conclusions it seems that surrogate liver function tests and adipocytokine levels were correlated with the histologic findings of the liver. objectives the aim of the study was to evaluate the correlation between serum adipocytokines and the histologic findings of the liver in patients with non-alcoholic fatty liver disease (nafld). patients and methods this case-control study was performed on ...

  Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice.   Materials and Methods:   Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the ...

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) used to create a mouse model steatohepatitis (NASH). There are some reports on the effects mice being fed CDAHFD for long periods 1 3 months. However, effect this over short period is unknown. Therefore, we examined 1-week feeding li...

Background: HCV chronic infection is a leading cause of end-stage liver disease and transplantation. The aim our study was to assess the benefits novel anti-HCV therapeutic approaches in obtaining viral clearance, reducing inflammation, regression fibrosis, improvement liver-related morbidity mortality.

AIMS Accurate liver fibrosis staging is crucial for the management of chronic hepatitis C (CHC). The invasiveness and cost burden of liver biopsy have driven the search for new noninvasive biomarkers of fibrosis. Based on the link between serum angiopoietin-1 and 2 levels and CHC progression, we aimed to determine the value of these angiogenic factors as noninvasive biomarkers of liver fibrosis...

Liver fibrosis is the final pathway for most chronic liver disease and is the main reason for increased mortality in affected patients. The extent of liver fibrosis displays great individual variation, even after controlling for age (at infection), gender & exogenous factors. Thus, host genetic factors are likely to play an important role in the process of liver scarring. (Weber et al., 2008). ...