Leaf & Neuberger (1947) reported that feeding rats with diets low in protein or sulphur-containing amino acids produced a marked and rapid fall in the reduced glutathione level of the liver to 20-30% of the normal value. The authors stated that the original purpose of their work was 'to find out whether the acute massive necrosis of the liver observed in rats reared on diets containing only tra...

Artemisinin is a powerful antimalarial drug, useful in the treatment of many diseases, including chickens coccidiosis. Its toxic effects have been well studied humans and experimental animals, but not sufficiently broiler chickens. Therefore, present study, we aimed to assess side artemisinin chickens, by measuring serum level proteins enzymes (ALT, AST, GGT, ALP, CK), histopathological examina...

Diclofenac, the anti-inflammatory drug, is found in natural water bodies all over the world. Toxicological researches of diclofenac report harmful effects on aquatic species even at low concentrations. The aim of present study was to determine whether diclofenac affected on the gills, liver and kidney of common carp (Cyprinus carpio). In order to evaluate toxic effects of diclofenac as NASIDs (...

A man with acute myelogenous leukemia, treated with chemotherapy, had a decrease in circulating formed blood elements. Bone marrow biopsy revealed necrosis. Imaging with In-Ill chloride demonstrated activity in the liver, but not in the spleen or bone marrow. Eighteen days later, the circulating blood count had risen; a repeat bone marrow biopsy showed the return of blood cell precursors....

Persian sturgeon, Acipenser persicus is a native, commercially important and highly steemed fish species in the Caspian Sea. In this study, effects of Nodularin (NODLN), a cyclic pentapeptide hepatotoxin, on liver and gill tissues of A. persicus were studied. Nodularin was produced in high amounts by Nodularia spumigena, a cyanobacterium species during the algal bloom in the Caspian Sea an...

Background: The aim of the present study was to find the effects of cadmium (Cd) on Japanese quail on the role of an animal model in order to understand the toxicity of Cd in creatures presented, within the environment. Methods: One hundred 30-day-old male Japanese quails were equally divided into the control group and Cd group. The control group received no Cd while the Cd group was given f...

conclusions the apri had the highest sensitivity and specificity (64% and 71%, respectively) for prediction of the presence of liver disease. we suggest that apri may be applicable for the detection of a severe liver disease. objectives in this study, we evaluated and compared several available indices of the severity of liver diseases in patients with hepatitis. patients and methods exclusion ...

The histopathological effects of Linear Alkylbenzene Sulfonate on the gill, liver and kidney tissues of the Caspian kutum, Rutilus frisii kutum were studied. The fish were exposed to three sublethal concentrations of anionic detergent, Linear Alkylbenzene Sulfonate (LAS) for short term intervals (192 h). Gill, liver and kidney samples were collected after 192 h of exposure to LAS and lesions we...