Introduccion La enfermedad de Weber-Christian es una paniculitis nodular recidivante, no supurativa, febril, mas frecuente en las mujeres jovenes. Se caracteriza por brotes recurrentes nodulos subcutaneos, distribucion simetrica. Tiene un origen idiopatico o secundaria a pancreatica, agentes fisicoquimicos deficit alfa-1-antitripsina. Puede afectar cualquier tejido del organismo que tenga grasa...

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an infrequent cytotoxic T-cell lymphoma of the skin with a unique immunophenotypic profile. Here we describe this lymphoma in a 30-year-old Iranian woman. She presented with periorbital edema, mandibular swelling with edematous areas on her face and two small lymph nodes (6-7mm) in the cervical area. Histopathological findings revealed l...

Through the International Registry of Pediatric Granulomatous Arthritis (PGA), we now identified 5 children with this disorder, all manifesting from very young age panniculitis, fever, hepatosplenomegaly, arthritis, uveitis and acute phase response. Underlying infections, immune deficiency and autoimmune disease, were excluded. No CARD15 or CIAS1 mutations were found. Histologically, the subcut...

Neutrophilic Lobular Panniculitis as an Expression of aWidened Spectrumof Familial Mediterranean Fever Familial Mediterranean fever (FMF) is considered to be an autosomal recessive disease, though it is controversial.1-3 The marenostrin-encoding fever gene (MEFV) is responsible for FMF. The most frequent mutation is M694V, which represents a genetic risk factor for development of amyloidosis1 a...

REPORT OF A CASE A woman in her 70s had right frontal anaplastic astrocytoma (World Health Organization grade III). The patient underwent a gross total tumor resection and a 6-week course of postoperative radiation therapy (6000 cGy) with concurrent TMZ (75 mg/m) by mouth daily. Four weeks after completion of radiation, she started adjuvant TMZ (150 mg/m by mouth), following the standard schedu...

Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis in childhood, associated either with nonmalignant conditions or with subcutaneous panniculitis-like T-cell lymphoma (SPTCL), and often also associated with macrophage activation syndrome (MAS). Discriminating between these 2 conditions is therapeutically important because nonmalignant CHP often improves under cyclosporine and pred...

A healthy G5P3 34-year-old Hispanic patient with a new diagnosis of granulomatous mastitis the right breast was referred to dermatology clinic for painful skin lesions that had enlarged over week prior and arthralgia in her knees elbows. Examination revealed multiple tender, erythematous subcutaneous nodules scattered extensor surfaces bilateral upper lower extremities. Histology from forearm e...

Dear Editor, A 23-year-old Malay woman with no past medical illness was admitted for a 4-day history of epigastric pain, vomiting and drowsiness. Investigations showed a high anion-gap metabolic acidosis with elevated serum ketones and hyperglycaemia, consistent with diabetic ketoacidosis (DKA). Anti-glutamic acid decarboxylase autoantibodies were positive, consistent with type 1 diabetes melli...