The International Liaison Committee on Resuscitation (ILCOR) Advisory Statement on Education and Resuscitation in 2003 included a hypothetical formula--'the formula for survival' (FfS)--whereby three interactive factors, guideline quality (science), efficient education of patient caregivers (education) and a well-functioning chain of survival at a local level (local implementation), form multip...

The present study reports on the epicardial spread of excitation during premature beats and during the initial stages of ventricular fibrillation, both of which were induced by single-test stimuli during regional ischemia or local hypothermia. Simultaneous recording of the activity at 48 epicardial sites on the right ventricle of dog hearts enabled us in some instances to demonstrate a circus m...

BACKGROUND The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model. METHODS Pigs were randomized to pre-reperfusion hypothermia (n = 7), post-reperfusion hypothermia (n = 7) or normothermia (n = 5). A percutaneous coronary intervention balloon was inflated in the left anterior descend...

IN THE PAST DECADE hypothermia has been a subject of intense experimental and clinical study.'-6 After initial experiences showed its severe limitations for intracardiac surgery, many technics of hypothermia were gladly discarded as pump-oxygenators were developed. Subsequently, the combination of hypothermia and extracorporeal circulation has permitted degrees of hypothermia previously incompa...

OBJECTIVES Local cryotherapy is widely and empirically used in the adjuvant setting in rheumatoid arthritis treatment, however its own therapeutic and anti-inflammatory effects are poorly characterized. We aimed to evaluate the effects of local cryotherapy on local and systemic inflammation in Adjuvant-induced arthritis, a murine model of rheumatoid arthritis. METHODS The effects of mild hypo...

STROKE is, according to the World Health Organization (10), the third most common cause of death in the developed countries, exceeded only by coronary heart disease and cancer. Annually, 15 million people worldwide suffer a stroke. Of these 15 million people, 5.5 million die and 5 million are left permanently disabled, placing a burden on family and community. The incidence of stroke is declini...

STROKE is, according to the World Health Organization (10), the third most common cause of death in the developed countries, exceeded only by coronary heart disease and cancer. Annually, 15 million people worldwide suffer a stroke. Of these 15 million people, 5.5 million die and 5 million are left permanently disabled, placing a burden on family and community. The incidence of stroke is declini...

STROKE is, according to the World Health Organization (10), the third most common cause of death in the developed countries, exceeded only by coronary heart disease and cancer. Annually, 15 million people worldwide suffer a stroke. Of these 15 million people, 5.5 million die and 5 million are left permanently disabled, placing a burden on family and community. The incidence of stroke is declini...

OBJECTIVE To identify the barriers to implementation of mild therapeutic hypothermia for adult survivors of cardiac arrest. Despite scientific evidence to support therapeutic hypothermia for resuscitated cardiac arrest patients, it is inconsistently and at times inadequately used. DESIGN Qualitative study, using semistructured interviews. SETTING A stratified random sample of 14 sites from ...