A key step in study of biosynthesis of membrane proteins is to look for the code that could be used to explain and predict which proteins would eventually be inserted in the membrane and which proteins would be secreted into the ER lumen when they cross the translocon channel. The aim of this work is to present an improvement of a previous method based on a local search approach. The proposed m...

One of the main advantages of portfolios over single assets is that risk can be diversified without necessarily reducing the expected return — provided the “right” assets are selected and they are assigned the “right” weights. Since in practice investors tend to restrict themselves to a rather small number of different assets, the decision which securities to include or not is a crucial one whi...

This study evaluates the retrieval of New Zealand information using three local New Zealand search engines, four major global search engines and three metasearch engines. Searches for NZ topics were carried out on all the search engines, and the relative recall calculated. The local search engines did not achieve higher recall than the global search engines or metasearch engines, but no search ...

In this paper a GRASP algorithm hybridized with a composite local search and path-relinking is proposed to solve the linear ordering problem with cumulative costs. Our approach consists on adding a composite local search that helps to produce diverse good solutions and improve them trough a truncated path-relinking with local search. The computational results show that the GRASP algorithm finds...

The optimal reactive power dispatch (ORPD) is a very important problem aspect of power system planning and is a highly nonlinear, non-convex optimization problem because consist of both continuous and discrete control variables. Since the power system has inherent uncertainty, hereby, this paper presents both of the deterministic and stochastic models for ORPD problem in multi objective and sin...