We performed scanning electron microscopy of an inverted blister roof in a case of pemphigus foliaceus. The loss of intercellular adherence could be easily seen with low magnification. The acantholytic keratinocytes displayed an irregular and sometimes polygonal contour. Round cells, typically seen in light microscopy, were also observed. The examination of a blister roof allows ultrastructural...

A case of cutaneous protothecosis was reported in a 78-year-old man that was in treatment for pemphigus foliaceus and phaeohyphomycosis. He presented erythematous lesions which were infiltrated into his right leg. The diagnosis was made histopathologically and confirmed by culture, and the patient was successfully treated with itraconazole.

Myasthenia gravis is an archetypal human autoimmune disease. Thymectomy proven effective by controlled clinical trials, and commonly part of the immunotherapeutic approach when myasthenia creates generalized weakness. Pemphigus foliaceus also but treated medically; thymectomy not therapy unless thymoma discovered. Autoimmune mechanisms, age distribution, response to in disorders are likely be d...

diseases and is divided into two vulgaris and foliaceus pemphigus and mainly appears during fifties and sixties.1,2 Its etiology is not exactly known and genetic talent may play a role in its development.3,4 The disease is globally widespread and is more common in some races.5,6 A study was conducted to evaluate the HLA-class I in patients suffering from pemphigus. Patients with skin biopsy of ...

Sir, The literature reports several cases of psoriasis associated with bullous diseases, the most frequent of which is bullous pemphigoid (1 – 3). By contrast, pemphigusrelated disorders are less frequently reported in association with psoriasis. We report the case of a patient with long-standing psoriasis who developed pemphigus foliaceus and discuss the possible pathogenic relationship betwee...

The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. Th...

Pemphigus foliaceus (PF) is a rare autoimmune blistering disease presenting in endemic and sporadic forms. The typical presentation is recurrent shallow erosions in a seborrheic distribution. We present a case of a 58-year-old woman with PF who was successfully treated with a combination of oral corticosteroids and dapsone. We also provide a concise review of the literature and discuss the etio...

Endemic pemphigus foliaceus, known as Fogo Selvagem (FS) in Brazil, is a disease characterized by subcorneal blisters and IgG4 anti-dermoglein 1 (Dsg1) autoantibodies. Epidemiological studies of FS strongly an environmental etiology. A 15-year surveillance of the Limao Verde Amerindian reservation in Brazil has uncovered information on the transition of the autoimmune response from the pre-clin...

Fifty patients with pemphigus (45 pemphigus vulgaris, 5 pemphigus foliaceus) were treated with dexamethasone-cyclophosphamide pulse therapy. The pulse consisted of 136 mg dexamethasone dissolved in 5% dextrose given in a drip over a period of 1-2 hours on 3 consecutive days. In addition, 500 mg cyclophosphamide was added in the drip on the first day. Such pulses were given at monthly intervals....