Um novo alcalóide, denominado histrixnina (1), e cinco alcalóides indólicos conhecidos, ibogamina (2), olivacina (3) e affinina (4), affinisina (5) e N b -metilaffinisina (6), foram isolados do extrato metanólico das cascas das raízes de Tabernaemontana hystrix. Os triterpenos conhecidos 3O-acetil-α-amirina, 3-O-acetil-β-amirina, 3-O-acetil-lupeol foram também identificados. As estruturas dos c...

In continuation of our studies on the phytochemical investigation of medicinal plants available in the foothills of Darjeeling and Teri, we report herein the isolation of two triterpenoids betulinic acid and lupeol from the leaf extract of Psidium guajava and their potential antimicrobial and phytotoxic activities. All the structures of the isolated compounds were confirmed by spectral (IR, NMR...

A new benzylic diglycoside was isolated from the leaves of Milicia excelsa and identified as 3,4-dimethoxybenzyl beta-D-xylopyranosyl (1 --> 2)-beta-D-glucopyranoside (1). It was obtained together with four known secondary metabolites including lupeol acetate (2), ursolic acid (3), triacontyl (E)-ferulate (4), and 2-(3,5-dihydroxyphenyl)benzofuran-5,6-diol (5). Their structures were determined ...

Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with an LC(50) of 1031 microg/ml. The two main compounds present in the most active ...

O estudo de Trattinnickia burserifolia levou ao isolamento dos triterpenos conhecidos ursanos α-amirenona, α-amirina, 3-epi-α-amirina, 3α,16β-diidroxiurs-12-eno; oleananos β-amirenona, βamirina, 3-epi-β-amirina, 3α,16β-diidroxiolean-12-eno; tirucalanos ácidos 3α-hidroxitirucal-8,24dien-21-óico, 3α-hidroxitirucal-7,24-dien-21-óico, e 3-oxotirucal-8,24-dien-21-óico; damaranos dammarenediol-II e 3...

Ficaprenol-11 (polyprenol) (1), squalene (2), lupeol (3), -sitostenone (4), trans-coumaric acid (5), cis-coumaric acid (6) pheophytin-a (7), pheophorbide a methyl ester (8), methyl-13-hydroxy-(13-S)pheophorbide-b (9) and aristophyll-C (10) were isolated from the whole plants of Leucaena leucocephala (Leguminosae). Among them, 1 and 2 was found for the first time from this species. The structur...

In continuation of our investigation on bioactive molecules, the melanin promotion activity-guided fractionation of the methanolic extract of the bark of Crataeva nurvala, yielded two known triterpenoid derivatives, lupeol (1) and lupenone (2). the structure of the compounds were established by physical and spectral data (UV, Ir, 1H, 13c nMr and Mass). the compounds were shown potent melanin pr...

Asteracantha longifolia (L.) Nees, Acanthaceae, is a source of the ayurvedic drug, ‘Kokilaaksha’ and the Unani drug, Talimakhana. The seeds are acrid, bitter, aphrodisiac, tonic, sedative, used for diseases of the blood. The plant is known to possess antitumor, hypoglycemic, aphrodisiac, antibacterial, free radical scavenging and lipid peroxidation, hepatoprotective and haematopoietic activity....

Ten new cembranolides, (-)-(1R*,4R*,10R*)-4-methoxycembra-2E,7E,11Z-trien-20,10-olide (1), (-)-(1S*,4R*,10R*)-1-hydroxy-4-methoxycembra-2E,7E,11Z-trien-20,10-olide (2), (-)-(1S*,4S*,10R*)-1,4-dihydroxycembra-2E,7E,11Z-trien-20,10-olide (3), (-)-(1S*,4S*,10R*)-1,4-dihydroxycembra-2E,7E,11Z-trien-20,10-olide (4), (+)-(10R*)-cembra-1E,3E,7E,11Z,16-pentaen-20,10-olide (5), (+)-(10R*)-cembra-1Z,3Z,7...