We present functional and binding data relevant to the reported roles for prothrombin and beta 2-glycoprotein I (beta 2GPI) in the expression of lupus anticoagulant activity. In a purified system containing human prothrombin, Xa, Va, and a rate-limiting concentration of phosphatidylserine (PS)/phosphatidylcholine (PC) vesicles, the preliminary incubation of vesicles with protein A separated IgG...

Two young adults with lupus anticoagulant had multiple attacks of cerebrovascular ischemia in different arterial territories. Cerebral angiography was normal. One patient had a new episode during anticoagulant therapy, but has remained asymptomatic on antiplatelet treatment. In the other, further events occurred during treatment with platelet-inhibiting drugs, but there have been no recurrences...

Lupus anticoagulant, first observed in 1952 in two patients with systemic lupus erythematosus (SLE), was linked to a phospholipid antigen when positive Wassermann tests for syphilis coincided with the lupus anticoagulant, documenting the lipid nature of the antigen. Bowie and colleagues were the first to unravel the paradoxical prothrombotic tendency of patients with positive lupus anticoagulan...

Background: Severe preeclampsia is a quite well-known entity with high incidence of both maternal and fetal morbidity and mortality. Although little is known about its etiology, inherited disorders of hemostasis and antiphospholipid syndrome have been postulated as common causes. The present study was conducted to evaluate the association of these two entities with preeclampsia in a group of Ir...

Although observations have implied that lupus anticoagulants have immunologic specificity toward anionic phospholipids. this assumption has been directly demonstrated in only one patient with a monoclonal 1gM paraprotein. We tested the generality of this hypothesis directly by isolating five lgG lupus anticoagulants from patients with lupuslike syndromes and/or thrombosis. lgG lupus anticoagula...

We reported a 26-year-old female who had experienced 2 miscarriages associated with a possible cause of antiphospholipid antibody. She consulted to Kainan Municipal Hospital with major complaints of miscarriages and positive antiphospholipid antibody. No evidence of obstetric disorder was apparent and routine haematological parameters were normal. Serological studies and clinical evidence did n...

Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS), a very rare disease that is caused by the presence of antifactor II antibodies, is usually counterbalanced by the prothrombotic effect of lupus anticoagulant (LAC). Patients with LAHPS are treated using fresh frozen plasma, steroids, immunosuppressive agents, and immunoglobulins for managing the disease and controlling hemorrhages. Notab...

OBJECTIVE Lupus anticoagulant and anticardiolipin antibodies (aCL) have been associated with thrombosis, recurrent abortion, and thrombocytopenia in patients with systemic lupus erythematosus (SLE), but their relationship with cardiac disease is less clear. The purpose of this study was to evaluate the association between antiphospholipid antibodies (aPL) and echocardiographic abnormalities in ...

BACKGROUND Sneddon's syndrome is a disease characterized by livedo reticularis and cerebrovascular lesions, with a hereditary transmission and unknown etiopathogenesis. A number of reports have documented a link between antiphospholipid antibodies and Sneddon's syndrome with different results. The present work was designed to sequentially study antiphospholipid antibodies in a patient with Sned...

In order to determine the role of different anti-phospholipid antibodies as an etiologic factor in recurrent pregnancy failure, a prospective study was done on one-hundred and thirty-eight women who had unexplained recurrent pregnancy loss (group I) with one-hundred well-matched women with normal reproductive outcome allocated as control group (GIl). Sera from 138 patients and 100 controls...