Lycium barbarum has been used as a traditional Chinese medicine to nourish liver, kidneys and the eyes. However, the underlying mechanisms of its hepatic-protective properties remain uncertain. In this study, we aimed to investigate whether thioredoxin-interacting protein (TXNIP) and NOD-like receptor 3 (NLRP3) inflammasome mediated the attenuation of ethanol-induced hepatic injury by Lycium ba...

AIM To investigate the protective effect and its mechanism of lycium barbarum polysaccharides (LBP) against oxidative stress-induced apoptosis in human retinal pigment epithelial cells. METHODS ARPE-19 cells, a human retinal pigment epithelial cell lines, were exposed to different concentrations of H2O2 for 24h, then cell viability was measured by Cell Counting Kit-8 (CCK-8) assay to get the ...

The active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mo...

Lycium barbarum polysaccharide (LBP) has traditionally been used in Chinese medicine as a chief ingredient of Lycium barbarum (wolf berry/goji berry) for the treatment of various diseases with the symptoms of frequent drinking and urination. This study was conducted as a randomized, controlled clinical trial. A total of 67 patients with type 2 diabetes (30 in control group and 37 in LBP group) ...

The present research study was undertaken at poultry research unit of Agricultural University, Peshawar, Pakistan in June-July, 2010 to investigate the effect of different timings of supplementing medicinal plants (Berberis lycium, Allium stivum, Solanum nigrum and Terminalia arjuna) infusion on the liver function and lipid profile of broiler at day-42. 240 day-old boiler chickens were randomly...

This study was to compare the relative level of antioxidant activity of methanolic extract of root bark of Berberis lycium Royle., in different test systems of antioxidant determination i.e ABTS (2,2’-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid) radical cation assay, Phosphomolybdenum assay and reducing power assay. In all these assays the antioxidant activity of extract was compared to t...

OBJECTIVE To study whether Lycium barbarum glycopeptide 3 (LBGP3) affects T cell apoptosis in aged mice. METHODS LBGP3 was purified with DEAE cellulose and Sephadex columns. Apoptotic "sub-G1 peak" was detected by flow cytometry and DNA ladder was resolved by agarose gel electrophoresis. Levels of IFN-gamma and IL-10 were measured with specific kits and mRNA expression was detected by RT-PCR....

Berberis aristata known as "Daruharidra" in Ayurveda is a versatile medicinal plant used singly or in combination with other medicinal plants for treating a variety of ailments like jaundice, enlargement of spleen, leprosy, rheumatism, fever, morning/evening sickness, snakebite, and so forth. A major bioactive marker of this genus is an alkaloid berberine, which is known for its activity agains...

Lycium barbarum has been used for more than 2500 years as a traditional herb and food in China. We investigated the effects of Lycium barbarum polysaccharides (LBP) on apoptosis, oxidative damage, and expression of adhesion molecules in bone marrow mononuclear cells (BMNC) of mice injured by ionizing radiation. Kunming mice were exposed to X-rays; then mice in the LBP groups were continuously i...

The importance of tuco-tucos (Ctenomys eremophilus) and cavies (Microcavia australis) as herbivores in the Monte Desert was assessed on a creosotebush community dominated by Larrea cuneifolia. Herbivory by tuco-tucos or cavies affected 35% of the total plants. The most highly damaged plant species was Atriplex lampa, followed by Larrea cuneifolia and Lycium sp. The level of damage caused by Cte...