نتایج جستجو برای: lymphatic diseases
تعداد نتایج: 862288 فیلتر نتایج به سال:
The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on the physiological uniqueness of the system. The lymphatic route plays an important role in transporting extracellular fluid to maintain homeostasis and in transferring immune cells to injury sites, and is able to avoid first-pass metabolism, thus acting as a bypass route for compounds with lower b...
Antiangiogenic therapy for the treatment of cancer and other neovascular diseases is desired to be selective for pathological angiogenesis and lymphangiogenesis. Macrophage colony-stimulating factor (M-CSF), a cytokine required for the differentiation of monocyte lineage cells, promotes the formation of high-density vessel networks in tumors and therefore possesses therapeutic potential as an M...
................................................................................................................................... 7 REVIEW OF THE LITERATURE ............................................................................................ 8 The formation of blood and lymphatic vessel networks during embryonic development .................... 8 Vasculogenesis and angiogenesis..........
The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mechanisms regulating lymphangiogenesis remain largely unknown. Here, we show that COUP-TFII (also known as Nr2f2), an orphan member of the nuclear receptor superfamily, mediates both developmenta...
The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged. This overview highlights recent advances in our understanding of the molecular mechanisms underly...
A case of generalised lymphatic abnormality that presented with hydrops fetalis is described. This seems to be the first such case reported.
background: management of lymphedema is a challenging issue in surgery. a variety of operations have been used, albeit with little success. objective: to investigate the efficacy of testicular patch as a lymphatic conduit. methods: an incision was made on the inguinal area of 10 dogs and all lymph nodes of inguinal area were excised. the tunica albuginea and parenchyma near the hilum of testes...
Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with vascular diseases, such as atherosclerosis, and promotes endothelial cell proliferation and apoptosis. Here, we identified an important role for disturbed flow in lymphatic vessels, in which it cooperates with the transcription factor FOXC2 t...
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