Altered morphological response of lymphocytes in the presence of antigenic stimulus in vitro may constitute an inter.sting clue to the knowledge of immunological mechanisms in multiple sclerosis (MS). It may serve as a diagnostic test and help in the evaluation of the clinical effect of anti-inflammatory and immunosuppressive agents (Hughes, Caspary, and Field, 1968; Saunders, Knowles, and Fiel...

The reactivity of lymphocytes to Treponema pallidum antigen was studied before and after treatment in nine patients with early syphilis using a leucocyte migration test and a lymphocyte transformation test. Lymphocyte reactivity was also investigated in six patients treated for syphilis within the last 4 years, and in five untreated patients with a positive result to the T. pallidum immobilizat...

Lymphocyte transformation to phytohaemagglutinin (PHA) was measured simultaneously by two methods (heparin and methyl cellulose) in 16 patients with non-lymphoid cancer and 21 normal subjects. Twelve cancer patients showed transformation levels below the normal heparin range, but only two patients showed levels below the normal methyl cellulose range. These findings suggest that in interpreting...

Forty-three untreated patients with ease. There is also no correlation beHodgkin’s disease were evaluated between lymphocyte transformation and tween 1965 and 1967 with PHA-stimuthe histologic pattern of nodular scierlated peripheral leukocyte cultures. No osis. Although PHA-induced lymphocorrelation was found between PHAcyte transformation appears to be a induced lymphocyte transformation at g...

The cross-reactivity of four Coccidioides antigens, three Histoplasma antigens, and two Blastomyces antigens were determined in lymphocyte transformation assays of 11 coccidioidin-reactive, histoplasmin-nonreactive subjects (group I), 13 coccidioidin-nonreactive, histoplasmin-reactive persons (group II), and 13 subjects who were skin test negative to both antigens (group III). Mycelial and yeas...