The vitamin E analogue alpha-tocopheryl succinate (alpha-TOS) is an efficient anti-cancer drug. Improved efficacy was achieved through the synthesis of alpha-tocopheryl maleamide (alpha-TAM), an esterase-resistant analogue of alpha-tocopheryl maleate. In vitro tests demonstrated significantly higher cytotoxicity of alpha-TAM towards cancer cells (MCF-7, B16F10) compared to alpha-TOS and other a...

The supernatant from centrifugation at 1,000 x g of strained rumen fluid was lyophilized, and the residue and sublimate fractions were used to replace fresh rumen fluid in a complete roll tube medium for enumeration of total rumen bacteria. Most of the growth-supporting nutrients in fresh rumen fluid were found in the residue fraction. With one exception, no significant differences were found i...

Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics Classification System (BCS) class II drugs. In this study, we aimed to improve raloxifene hydrochloride (RLX), a BCS drug, using self-microemulsifying drug delivery system (SMEDDS). Based on solubilities RLX, Capryol 90, Tween 80/Labrasol ALF, polyethylene glycol 400 (PEG-400) were selected as oil, surfac...

Lyophilizing was compared to freezing as a method of colostrum storage. Eight lots of colostrum from the first milking were divided into two equal parts; one was frozen, and the other was lyophilized. Twenty-two newborn calves were divided into two groups and fed either 2 L of frozen and thawed colostrum or 2 L of reconstituted lyophilized colostrum. The calves were bled at 12, 18, 24, and 72 h...

Flaxseed (Linum usitatissimum L.) is the seed of a multipurpose plant pharmaceutical interest, as its mucilage can be used natural matrix to develop extended-release dosage forms and potentially replace synthetic polymers. In this study, 3² factorial design with two replicates central point was applied optimize development granules metformin HCl. The total fiber content well friability dissolut...

In this work, air lime mortars were bioformulated with two innovative bioproducts, one resulting from iron supplemented Escherichia coli cultures and a second exploiting microbial mixed grown crude glycerol as substrate. The bioproducts lyophilized and, for the mortar formulation, suspended in water used mixing liquid. Workability of was evaluated by flow table consistency 90-days-old samples t...

The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome dose-dependent side effects improve its bioavailability at site action. optimization done using 32 factorial design approach wherein soya phosphatidylcholine (SPC) cholesterol (CH) as...

Determination of moisture content in lyophilized solids is fundamental to predict quality and stability of freeze-dried products, but conventional methods are time-consuming, invasive and destructive. The aim of this study was to develop and optimize a fast, inexpensive, noninvasive and nondestructive method for determination of moisture content in lyophilized mannitol, based on an NIR micro-sp...

Using a Technicon SMAC continuous-flow instrument, we compared a liquid quality-control material ("Decision level 3," Beckman) with two different lyophilized quality-control materials. The variances for 19 analytes in the three materials were significantly greater for Decision than for the Ortho Abnormal and the Omega II lyophilized control sera (p less than 0.00001 for each comparison by the o...

Radioimmunotherapy (RIT) of Non-Hodgkin’s lymphoma (NHL) is said to be more advantageous compared to unlabelled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb radioimmunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic ...