Detection of high-risk subjects in acute myocardial infarction (AMI) by noninvasive means would reduce the need for intracardiac catheterization and associated complications. Liver enzymes are associated with cardiovascular disease risk. A potential predictive value for liver serum markers for the severity of stenosis in AMI was analyzed.Patients with AMI undergoing percutaneous coronary interv...

For many studies, participants' sleep-wake patterns are monitored and recorded prior to, during and following an experimental or clinical intervention using actigraphy, i.e. the recording of data generated by movements. Often, these data are merely inspected visually without computation of descriptive parameters, in part due to the lack of user-friendly software. To address this deficit, we dev...

The morphine alkaloid hydromorphone (dihydromorphinone) was identified as an intermediary metabolite in the degradation of morphine by Pseudomonas putida M10. A constitutive NADH-dependent morphinone reductase capable of catalyzing the reduction of the 7,8-unsaturated bond of morphinone and codeinone, yielding hydromorphone and hydrocodone, respectively, was shown to be present in cell extracts...

The purpose of this note is to prove two statements on the slopes of effective divisors on the moduli space of stable curves Mg: first that the Harris-Morrison Slope Conjecture fails to hold on M10 and second, that in order to compute the slope of Mg for g ≤ 23, one only has to look at the coefficients of the classes λ and δ0 in the expansion of the relevant divisors. The proofs are based on a ...

The NADH-dependent morphinone reductase from Pseudomonas putida M10 catalyses the reduction of morphinone and codeinone to hydromorphone and hydrocodone respectively. Morphinone reductase was purified from crude cell extracts to apparent homogeneity in a single affinity-chromatography step using Mimetic Yellow 2. The purified enzyme was a dimeric flavoprotein with two identical subunits of M(r)...

Abstract Background Fungi biosynthesize a wide range of chemically diverse secondary metabolites during processes competition with other micro- and macro-organisms, symbiosis, parasitism, or pathogenesis. Some these natural compounds have antibiotic properties, which allow the microbe to inhibit and/or kill their microbial competitors. Results In course an ongoing search for novel bioactive fro...

The freezing process. microstructures and phase relationships in some experimental cast tool steels have been investigated and developed under the various solidification conditions. Experimental steels were based on AISI M2 and M10 grades high speed steels. Addition of carbide forming elements such as niobium and titanium with and without extra carbon were made to the molten bath of the base st...