Dasotraline is a dopamine and norepinephrine reuptake inhibitor, and the early clinical trials show a slow absorption and long elimination half-life. To investigate the absorption, distribution, metabolism, and excretion of dasotraline in humans, a single dose of [C]-dasotraline was administered to eight healthy male adult volunteers. At 35 days, 90.7% of the dosed radioactivity was recovered i...

The linear instability of the electron temperature gradient (ETG) driven modes in the presence of zonal flows is investigated. Random and deterministic cos like profiles of the zonal flow are considered. It is shown that the presence of shearing by zonal flows can stabilize the linear instability of ETG drift modes. PACS numbers: 52.35.-g, 52.30.-q, 52.55.Fa, 52.35.Kt

In this paper we prove that the extended triplicate graph (ETG) of finite paths admits product E-cordial, total product E-cordial labelings. We show that ETG of finite paths of length n where n ∉ {4m-3|m∈N} admits E-Cordial, total E-cordial labelings and also we prove the existence of Z3 – magic labeling for the modified Extended Triplicate graph.

Modified Bellani plate atmometer has been offered as an alternative and simpler technique to combination-based equations to estimate evapotranspiration ~ET! rate from green grass surface. However, there is a lack of information on its’ accuracy in humid climates. The evaporation rate sEAd from one type of atmometer marketed under the brand name ETgage® ~or ETG! with a Number 30 green canvas cov...

RESUMO O óxido de grafeno (GO) é um nanomaterial carbono que apresenta propriedades únicas e dentre elas, a excelente condutividade térmica pode ser explorada em nanocompósitos, como também nanofluidos. etilenoglicol (ETG) fluido troca ter suas térmicas potencializadas pela adição GO. Porém, tanto o nível dispersão GO quanto reologia da suspensão, podem influenciar as características dos nanofl...

[Purpose] The purpose of the study was to determine the effects of training using virtual reality games on balance and gait ability, as well as the psychological characteristics of stroke patients, such as depression and interpersonal relationships, by comparing them with the effects of ergometer training. [Subjects] Forty stroke patients were randomly divided into a virtual reality group (VRG,...

Fatty acid ethyl esters (FAEE), direct metabolites of ethanol, are suitable alcohol markers that can be detected in different tissues. The determination of FAEE in hair can help to evaluate social and excessive alcohol consumption. Due to the presence of FAEE in the hair of teetotalers, proving alcohol abstinence seems to be impossible. To verify these results, an solid phase micro extraction-g...

To get a comprehensive view of fungal M35 family (deuterolysin) and M36 family (fungalysin) genes, we conducted genome-wide investigations and phylogenetic analyses of genes in these two families from 50 sequenced Ascomycota fungi with different life styles. Large variations in the number of M35 family and M36 family genes were found among different fungal genomes, indicating that these two gen...

We report the complex cytogenetic analysis of a novel melanoma cell line (M35/01) established from a vertical growth phase of a superficial spreading melanoma. Similarly to its parental tumor, this cell line metastasizes to the liver. Using combined molecular cytogenetic techniques, we could identify a reservoir of chromosomal alterations in M35/01. In addition, we had sufficient amount of DNA ...

After alcohol ingestion, the bulk of ethanol ingested ( 95%) is rapidly eliminated in the liver in a two-stage oxidation process: first to acetaldehyde by alcohol dehydrogenase and then to acetic acid by aldehyde dehydrogenase. The remainder is excreted mainly unchanged in urine and expired air. However, another small fraction of the ingested ethanol dose ( 0.1%) (1 ) undergoes a phase II conju...