The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive d...

Sir James Mackenzie is revered by general practitioners as the father of general practice-based research.' His name is associated with the University Department of General Practice at Edinburgh and with the Chair at Aberdeen, and he is commemorated in the James Mackenzie lecture given annually at the Royal College of General Practitioners. His fame rests largely on his achievements as a solitar...

Introduction the Burbot (Lota lota [L, 1758]) is a northern fish species with a circumpolar distribution in freshwater rivers, creeks, and lakes. Burbot live in cold lakes and rivers, where they tend to frequent deep water near the bottom (McPhail and Paragamian 2000). they can at tain a length of 1 m and a weight of 8 kg, although most fish are 0.3–0.6 m in length and weigh 1–3 kg (McPhail and...

We assayed microsatellite DNA variation among 1013 broad whitefish, Coregonus nasus, from 36 localities within the lower Mackenzie River (Northwest Territories, Canada) to provide the first assessment of fine-scale population structuring of broad whitefish in this large system. Among sampling locations, averaged across all loci, the number of alleles ranged from 3.00 to 6.71 and heterozygosity ...

The contemporary distribution of genetic variation within and among high latitude populations cannot be fully understood without taking into consideration how species responded to the impacts of Pleistocene glaciations. Broad whitefish, Coregonus nasus, a species endemic to northwest North America and the Arctic coast of Russia, was undoubtedly impacted by such events because its geographic dis...