Macrolide antibiotics are categorized by the WHO as Highest Priority, Critically Important Antimicrobials due to their recommendation treatment for severe cases of campylobacteriosis in humans; a self-limiting, rarely life-threatening, zoonotic foodborne infection. Low rates macrolide resistance Campylobacter jejuni and availability alternative treatments have prompted some regulatory schemes a...

Macrolide antibiotics, such as erythromycin, bind to the nascent peptide exit tunnel (NPET) of bacterial ribosome and modulate protein synthesis depending on sequence. Whereas in vitro biochemical structural methods have been instrumental dissecting explaining molecular details macrolide-induced peptidyl-tRNA drop-off stalling, dynamic effects drugs ongoing inside live cells are far less explor...

Exemplified by a representative selection of macrolide natural products, this personal perspective reflects on the trials, tribulations and serendipitous discoveries experienced in pursuit their total synthesis exploiting aldol methodology.

intractable asthma is a challenging clinical problem. this study was conducted to determine whether a subset of patients with intractable asthma may be misdiagnosed and have a form of bronchiolitis instead and also to determine the effectiveness of macrolide therapy in these patients. seventy six patients with intractable asthma were re-treated with recommended maximal doses of oral prednisolon...

Macrolides represent a clinically important class of antibiotics that block protein synthesis by interacting with the large ribosomal subunit. The macrolide binding site is composed primarily of rRNA. However, the mode of interaction of macrolides with rRNA and the exact location of the drug binding site have yet to be described. A new class of macrolide antibiotics, known as ketolides, show im...

Macrolide resistance in Streptococcus pneumoniae has emerged as an important worldwide problem over the past decade. The aim of this study was to investigate macrolide-resistant phenotypes and the antimicrobial susceptibility patterns of invasive pneumococci in Serbia. A total of 68 invasive pneumococcal strains, collected from 2009 to 2011, were sent from regional laboratories to the national ...

BACKGROUND AND PURPOSE Mycoplasma pneumoniae infection is a major cause of community-acquired respiratory tract infection in children. We performed a retrospective study to evaluate clinical and demographic data and compare outcomes with and without macrolide treatment in children with M. pneumoniae infection. METHODS A total of 139 patients were included in the study and classified into two ...

In vitro resistance to antimicrobial agents is escalating among pathogens responsible for the most serious respiratory tract infections. Some reports have suggested that this has direct clinical implications. Because of penicillin and macrolide resistance in Streptococcus pneumoniae, current guidelines for the initial treatment of respiratory tract infections advocate less reliance on the use o...

objective(s): macrolide resistant streptococcus pneumoniae pose an emerging problem globally. the aim of this study was to investigate the prevalence of ermb and mefa genes (macrolide resistant genes) by polymerase chain reaction (pcr) method and to detect drug resistance patterns of s. pneumoniae isolated from clinical samples to macrolides and other antibiotic agents by e-test method. materia...

Strains of Saccharomyces cerevisiae FL200 capable of growing on a solid medium containing a mixture of polyene macrolide antibiotics (nystatin, 40 micrograms/ml, amphotericin B, 40 micrograms/ml, pimaricin, 150 micrograms/ml and RP9971 antibiotic, 10 micrograms/ml) have been isolated after successive selection steps. The mutant strains, PR13 and PRC24, are 10 to 100 times more resistant than th...