BACKGROUND Much controversy exists regarding the initial choice of antibiotics and selected outcomes for patients with community-acquired pneumonia (CAP). METHODS The investigators analyzed a hospital claims-made database to assess the impact of initial antibiotic choice on 30-day mortality, total hospital costs, and hospital length of stay (LOS). Fine risk groups allowed for stratification f...

Macrolide antibiotics are largely used in pregnancy for different bacterial infections. Their fetal safety has been studied by several groups, yielding opposing results. In particular, there have been studies claiming an association between macrolides and cardiovascular malformations. Exposure in early infancy has been associated with pyloric stenosis and intussusception. This has led to an avo...

Introduction Despite a proper management, the mortality of patients with severe sepsis and septic shock is very high. During sepsis, an uncontrolled cascade of inflammatory mediators is triggered, leading to tissue damage that can cause death. Macrolides, apart from their antibiotic properties, are capable of modulating inflammatory response. Macrolides inhibit the production and secretion of p...

Macrolides are effective in reducing the number of exacerbations COPD patients with frequent exacerbator phenotype. Our study did not show a persistent effect azithromycin on exacerbation frequencies after more than one year usage.

Aliphatic macrolides are used by various organisms as semiochemicals or pheromones, e.g. by the endemic Madagascan frog family Mantellinae. Volatile, methyl-branched aliphatic macrolides occur in various species, but their identification by MS is difficult, while isolation is not possible due to the low amounts produced. Therefore, we synthesized a library of methyl-branched 11-dodecanolides to...