HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...

In this review we summarize the most important procedures for the preparation of functionalized organzinc and organomagnesium reagents. In addition, new methods for the preparation of polyfunctional aryl- and heteroaryl zinc- and magnesium compounds, as well as new Pd-catalyzed cross-coupling reactions, are reported herein. Experimental details are given for the most important reactions in the ...

A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation with magnesium hydride (MgH2), which prepared in situ through solvothermal treatment iodide (MgI2) sodium (NaH) tetrahydrofuran. Downstream functionalization resulting propargylmagnesium intermediates organo nitro compounds affords α-alkynylnitrones, could be used ...

The kinetic properties of highly purified human placental cytoplasmic 5'-nucleotidase were investigated. Initial velocity studies gave Michaelis constants for AMP, IMP, and CMP of 18, 30, and 2.2 microM, respectively. The enzyme shows the following relative Vmax values: CMP greater than UMP greater than dUMP greater than GMP greater than AMP greater than dCMP greater than IMP. The activity was ...

Using monoanionic triazenide ligands derived from biphenyl and m-terphenyl substituted triazenes Dmp(Tph)N3H (1a), (Me4Ter)2N3H (1b) or Dmp(Mph)N3H (1c) (Dmp = 2,6-Mes2C6H3 with Mes = 2,4,6-Me3C6H2; Me4Ter = 2,6-(3,5-Me2C6H3)2C6H3; Mph = 2-MesC6H4; Tph = 2-TripC6H4 with Trip = 2,4,6-i-Pr3C6H2), several magnesium triazenides were synthesized. Heteroleptic complexes [Mg(N3Ar2)I(OEt2)] (Ar2 = Dmp/...

In the presence of magnesium and hexamethylphosphorictriamide, HMPT, trimethylchlorosilane, TMS-C1, reacts with cyanoepoxides to give related compounds. Ring cleavage at ? - position of cyanoepoxide, 1, followed by the addition of two trimethylsilyl groups leads to 2 then substitution of OSiMei by trimethylsilyl or H takes place to give ?, ? - bis (trimethylsilyl) nitrile or ? - trimethyls...

OBJECTIVE To review the components of calcium, phosphate and magnesium metabolism that are relevant to the critically ill patient, in a two-part presentation. DATA SOURCES A review of articles reported on calcium, phosphate and magnesium disorders in the critically ill patient. SUMMARY OF REVIEW Abnormal calcium metabolism in the critically ill patient often presents with an alteration in p...

Multinuclear organometallic species play a significant role in alkylation of carbonyl compounds. Enantioselective alkylation of aldehydes using a 1: 1 reagent/substrate stoichiometry is achievable by chirally modified lithium/magnesium binary organometallic reagents. For example, diethylmagnesium treated with di-O-lithio-(S)-2.2'dihydroxy1, 1'-binaphthyl reacts with benzaldehyde in a THFdimetho...