Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic mi...

conclusion a higher magnetic field strength and a decrease in the hr resulted in an increase in body temperature during the mri procedure. results our investigation of the physiological response to rf heating indicated a link between increasing age and body temperature. a higher increase in body temperature was observed in older patients after a 3.0-t mri (r = 0.07, p = 0.29 for 1.5-t mri; r = ...

Our purpose in this study was to present an integral-transform approach to the analytical solutions of the Pennes' bioheat transfer equation and to apply it to the calculation of temperature distribution in tissues in hyperthermia with magnetic nanoparticles (magnetic hyperthermia). The validity of our method was investigated by comparison with the analytical solutions obtained by the Green's f...

Targeting cancer cells without injuring normal cells is the prime objective in treatment of cancer. In this present study, solvothermal and wet chemical precipitation techniques were employed to synthesize iron oxide (IO), hydroxyapatite (HAp), and hydroxyapatite coated iron oxide (IO-HAp) nanoparticles for magnetic hyperthermia mediated cancer therapy. The synthesized well dispersed spherical ...

objective cerebral palsy (cp), a common static motor neurological disorder of childhood with wide spectrum of underlying etiologies, can be demonstrated with different neuro imaging techniques. we undertook this study to investigate the diagnosis of intracranial lesions in children with cp and its correlation between clinical deficits and neuroradiological findings. materials and methods in thi...

epilepsy is an important disease with a cumulative incidence of 3% all over the life and more than half of them are started from childhood. in this study we surveyed magnetic resonance imaging (mri) findings in epileptic children and its relation with clinical and demographic findings in order to find better diagnostic and treatment modalities for these children in the future. in this cross sec...

Superparamagnetic nanoparticles (SPIONs) could enable cancer theranostics if magnetic resonance imaging (MRI) and magnetic hyperthermia treatment (MHT) were combined. However, the particle size of SPIONs is smaller than the pores of fenestrated capillaries in normal tissues because superparamagnetism is expressed only at a particle size <10 nm. Therefore, SPIONs leak from the capillaries of nor...

Spatiotemporal control of transgene expression is of paramount importance in gene therapy. Here, we demonstrate the use of magnetic resonance temperature imaging (MRI)-guided, high-intensity focused ultrasound (HIFU) in combination with a heat-inducible promoter [heat shock protein 70 (HSP70)] for the in vivo spatiotemporal control of transgene activation. Local gene activation induced by moder...