Among 193 inpatients with Research Diagnostic Criteria (RDC) major psychiatric disorders, the scores in Hamilton's Rating Scale for Depression (HRSD) were higher among those patients with RDC schizoaffective disorder depressed type and major depressive disorder, whereas the scores in the Scale for Assessment of Negative Symptoms (SANS) were higher among patients with these two disorders, as wel...

Introduction Suicide is a complex and multicausal phenomenon. It has a strong association with mental disorders, particularly major depressive disorder. Suicidal behaviors (both fatal and non-fatal) in patients with mood disorders are determined by their severity. Suicidal acts likely occur during depressive episodes, less often during mixed states, and very rarely in hypomania. However, the pr...

OBJECTIVE To evaluate the comorbidity of depressive disorders in patients with refractory temporal lobe epilepsy (TLE). METHOD We evaluated 25 consecutive patients with refractory TLE (16 women and 9 men), using semi-structured psychiatric interviews, according to the International Classification of Diseases (ICD-10), and the Beck Depression Inventory. RESULTS Seventeen of 25 patients (68%)...

The link between burnout and depression remains unclear. In this study, we compared depressive symptoms in 46 burned-out workers, 46 outpatients experiencing a major depressive episode, and 453 burnout-free workers to test the distinctiveness of burnout as a clinical entity. Participants with burnout and major depressive episode reported similar, severe levels of overall depressive symptoms. Th...

background :5httlpr polymorphism (5- hydroxytryptamine transporter linked promoter region polymorphism) is the most widely studied genetic variant in psychiatry. the present study is a modest effort at ascertaining the role of 5ht transporter linked promoter region polymorphism (5httlpr) in anxiety and depressive disorders in kashmir (india).the aim of this study was to examine 5-hydroxy trypta...

BACKGROUND Though an important percentage of patients with chronic hepatitis C virus (HCV) undergoing interferon (IFN) therapy develop depressive symptoms, the role of the IFN system in the pathogenesis of depressive disorders is not well understood. METHODS 50 patients with HCV infection were treated with standard combination therapy (pegylated IFN-α2a/ribavirin). IFN-induced gene expression...

BACKGROUND Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease. METHODS AND FINDINGS Burden...

objective: major depressive disorder is a severe disorder that has a significant impact on the psychological and social functioning of children and adolescents. considering current limitations in the treatment of this disorder, the present study was performed to evaluate the efficacy of fluvoxamine in the treatment of children and adolescents with major depressive disorder. method: in an open t...

objective: suicide is one of the most important early causes of death in psychotic patients. the main object of this research was to determine the relationship between positive and negative symptoms of schizophrenia and psychotic major depressive disorder (mdd) with suicidal history and risk. methods: sixty five patients with schizophrenia compared to 65 patients with psychotic mdd in a cross s...