To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for identification of the emotional significance of a stimulus, production of affe...

Among 193 inpatients with Research Diagnostic Criteria (RDC) major psychiatric disorders, the scores in Hamilton's Rating Scale for Depression (HRSD) were higher among those patients with RDC schizoaffective disorder depressed type and major depressive disorder, whereas the scores in the Scale for Assessment of Negative Symptoms (SANS) were higher among patients with these two disorders, as wel...

Social stigma is a major challenge among the patients with mental illness, their families and the health care providers. Not only the patient with psychological disorders, but also who has an infectious disease suffer social stigma. Stigma refers to an extreme and unusual disapproval of a person from the other members of society. Stigma is a Greek word that in its origins referred to a type of ...

PURPOSE To study the rate of psychiatric disorder and suicidal behavior in children with thalassemia major. METHOD One hundred ten subjects with thalassemia major were interviewed according to the K-SADS Farsi version by face-to-face interview. RESULT The most common psychiatric disorders were major depressive disorder and separation anxiety disorder. The rate of oppositional defiant disord...

Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published ...