In this study, we tested the effect of the stilbene resveratrol on life span, body composition, locomotor activity, stress response, and the expression of genes encoding proteins centrally involved in ageing pathways in the model organism Drosophila melanogaster. Male and female w1118 D. melanogaster were fed diets based on sucrose, corn meal, and yeast. Flies either received a control diet or ...

BACKGROUND Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span. METHODS AND FINDINGS Serum IGF-I was reduced by approximately 80% in mice with adult, liver...

When given by direct s.c. injection into the Ehrlich solid carcinoma 1 week after s.c. tumor transfer, viable crude spores of Clostridium perfringens type A (attenuated mutant strain LNG11 ATCC 29348) inhibited tumor growth and significantly prolonged the life span of male outbred Swiss mice. Under these conditions a concentrated sterile supernatant of a C. perfringens culture proved to be slig...

The hematopoietic system is maintained throughout adult life by a population of immature precursors known as the multipotential stem cells . These stem cells are unique within the system in that they have the capacity to generate progeny of all the blood cell lineages, as well as the capacity to generate cells with a potential similar to their own, a characteristic often referred to as self-ren...

A conceptualization of coping and adaptation following victimization is presented from a life-span developmental perspective. Recovery is characterized as an evolving process of interaction among three dimensions: social cognition, environmental sensitivity, and emotional-behavioral functioning. The model is illustrated through an individual case study and through an approach to research on out...

There is a need for aging theories to become holistic and multidisciplinary with a life span focus. A theory is the construction of explicit explanations in accounting for empirical findings. A good gerontological theory integrates knowledge, tells how and why phenomena are related, leads to prediction, and provides process and understanding. In addition, a good theory must be holistic and take...

This chapter discusses the concept of resilience from a life span perspective informed by relational developmental systems theory. Resilience involves mutually benefi cial (adaptive) relations between characteristics of individuals (e.g., their self-regulation behaviors) and features of the ecology (e.g., resources promoting healthy development); these links may be represented as individual ←→ ...

perspectives on life span Life span should be considered within a larger biological framework concerned with life duration—a model where the end points of life for an individual do not necessarily correspond to the conventional events of birth PDR 29 Supp Carey.sp 7/6/06, 3:16 PM 1 2 L I F E S P A N : A C O N C E P T U A L O V E R V I E W and death. The concept of life span does not apply to ba...

Ovarian development, oviposition, larval eclosion, ornithine decarboxylase (ODC) activity, ovarian, testis and ejaculatory apodeme measurements (length, width, and area), and the number of spermatozoa of Anastrepha fraterculus (Wiedemann) were analyzed at alternating (20 degrees/6 degrees C and 20 degrees/13 degrees C) and constant (6 degrees C; 25 degrees C) temperatures. Life span and life ex...

Food restriction increases the maximal longevity of rats. Male rats do not increase their food intake to compensate for the increase in energy expenditure in response to exercise. However, a decrease in the availability of energy for growth and cell proliferation that induces an increase in maximal longevity in sedentary rats only results in an improvement in average survival, with no extension...