Bovine respiratory disease (BRD) continues to greatly affect beef, dairy, and veal production systems. Vaccination against the bacteria involved is common, yet questions remain regarding efficacy. The purpose of this review was evaluate evidence for effects vaccinating United States or Canadian calves Mannheimia haemolytica, Pasteurella multocida, Histophilus somni on BRD-related morbidity, mor...

The severity of bovine respiratory infections has been linked to a variety of factors, including environmental and nutritional changes, transportation, and social reorganization of weaned calves. Fatal respiratory infections, however, usually occur when a primary viral infection compromises host defences and enhances the severity of a secondary bacterial infection. This viral-bacterial synergy ...

We have determined the 1.35- and 1.45-A structures, respectively, of closed and open iron-loaded forms of Mannheimia haemolytica ferric ion-binding protein A. M. haemolytica is the causative agent in the economically important and fatal disease of cattle termed shipping fever. The periplasmic iron-binding protein of this gram-negative bacterium, which has homologous counterparts in many other p...

Mannheimia haemolytica (previously known as Pasteurella haemolytica) is a weakly hemolytic, gram-negative coccobacillus that is an opportunistic pathogen of cattle, sheep and other ruminants. In stressed, immunocompromised animals, the organism causes a fibrinous, necrotic pneumonia, commonly called "shipping fever". In the United States, economic losses due to shipping fever pneumonia surpass ...

A new variety of Pasteurella, named by Henriksen and Jyssum (1960, 1961) Past. haemolytica var. ureae, has been isolated from the sputum of 17 patients, most of them elderly, suffering from chronic bronchitis or bronchiectasis. It has also been found in the normal respiratory tract. Whether the organism aggravates the disease or acts as a mere commensal when growing in the damaged tissue is not...

Ten Pasteurella haemolytica isolates from the nasal passages of cattle, untypable by the indirect hemagglutination procedure, were grouped into three serotypes by the rapid plate agglutination procedure. Serological specificity and serum absorption results showed that the 10 indirect hemagglutination-negative isolates belonged to three distinct serotypes and were not members of established sero...

Bacterial isolations from tracheal and bronchial washes obtained with the aid of a fibreoptic endoscope were carried out over a 7 month period in a feedlot on calves suffering from acute pneumonic pasteurellosis. Pasteurella haemolytica and Pseudomonas aeruginosa represented the majority of isolates. Antibiotic sensitivities of the Pasteurella isolates are reported on.

Pasteurella haemolytica A1 crude leukotoxin (25%, vol/vol) rapidly diminished the bovine neutrophil chemiluminescence response to opsonized zymosan. This inhibition was neither prevented nor reversed by 75 mM sucrose. Dilute leukotoxin did not directly stimulate neutrophil chemiluminescence nor did it alter the chemiluminescence response of the neutrophils to opsonized zymosan.