Previous experiments investigating ERP correlates of anticipatory attention shifts triggered by central symbolic cues have identified a contralateral "early directing attention negativity," which was assumed to be generated by processes involved in the control of spatial orienting. Here we demonstrate that this component is not directly linked to the control of attentional shifts, but instead r...

Technology selection is an important part of management of technology. Recently Karsak and Ahiska (2005) proposed a novel common weight multiple criteria decision making (MCDM) methodology for selection of the best Advanced Manufacturing Technology (AMT) candidates based on a number of attributes. However, Amin et al. (2006), by means of a numerical example demonstrated the convergence difficul...

Introduction Manufacturing processes for therapeutic monoclonal antibodies (mAbs) have evolved immensely in the past two decades around two major thrust areas. 1) Advancements in a) Cell line developmentbreakthrough and incremental knowledge gain in technology b) Media and feed formulation strategies c) Advent of Disposables and Instrumentation technologies thus offering significant improvement...

This paper proposes an efficient algorithm for optimum allocation of tolerances among components of an assembly with an objective to minimize the total cost of manufacturing while meeting the tolerance specifications of the assembly. The assembly is first represented as a two-layer constraint network by describing its functions, attributes and then entities. Forward propagation of entity tolera...

Background It has always been an objective of process development and more recently it has also become a regulatory expectation to build robustness into and demonstrate proper control of a manufacturing process, thus ensuring that the biological product meets consistently its quality attributes and specifications. This is achieved mainly through systematic process development and understanding....

The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS) immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs), inf...

Today’s product demand and mix changes requiring reconfiguration of cells in each period of a multi-period planning horizon, This paper proposes a mixed-integer non-linear programming model for reconfigurable CMS design to meet changes in product mix & demand in each period of a multi-period planning horizon. The proposed model, to the best of author’s knowledge, is the most comprehensive model...

Proper selection of material in manufacturing firms is a vital role of designer depending upon the different era of application. The material selection problem is very complex and challenging task today. Erroneous cull of material frequently leads to astronomically immense cost involution, and finally drives towards unfortunate component or product breakdown. Thus, the designer necessitates dis...

Six Sigma is a strategy for achieving process improvement and operational excellence within an organization. Decisions on critical parameter selection in analysis phase are always very crucial; it plays a primary role in successful execution of Six Sigma project and for productivity improvement in manufacturing environment and involves the imprecise, vague and uncertain information. Using a cas...