Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bea...

Marburg virus (MARV) is a pathogenic zoonotic RNA etiologic for disease (MVD), severe hemorrhagic fever. This rare disease, with high fatality rate, that spreads via infected blood or body fluids indirectly fomites (contaminated objects and substances such as clothed, beds, personal protective equipment, medical equipments). A few vaccines to protect against MARV are undergoing clinical trials,...

Marburg Virus is a contagious virus belonging to the family Filoviridae, which shared by Ebola Virus. It leads disease typically characterized viral haemorrhagic fever (VHF). The infection can get systemic during late organ phase, eventually multi-organ dysfunction, thereby making it deadly disease. An important factor contributing its tissue tropism glycoprotein (MARV GP), while host of nucleo...

Marburg virus disease (MVD) is a highly fatal, but uncommon viral which causes infection accompanied by hemorrhage and fever. It caused (MARV), zoonotic belonging to the family of viruses known as Filoviridae, single stranded RNA negative-sense virus, marburgvirus species. was established have up 88% fatality rate. Fruit bat thought be natural host for well other non-human primate such grivet m...

Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen reported few individuals with sporadic outbreaks following 1967, rarity commensurate degree of disease severity. The known to cause extreme hemorrhagic fever presenting flu-like symptoms (as implicated COVID-19) 90% case fatality rate (CFR). After number plausible evidences, it obs...

The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a result of virally encoded immune antagonists, which render the host incapable of mounting effective innate or adaptive immune responses. The T...

The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus glycoprotein (GP) in place of the VSV glycoprotein (G). The main concern with all replication-com...

Filoviruses Ebolavirus (EBOV) and Marburgvirus (MARV) cause haemorrhagic fevers with high mortality rates, posing significant threats to public health. To understand transmission into human populations, filovirus dynamics within reservoir host populations must be understood. Studies have directly linked filoviruses to bats, but the mechanisms allowing viral persistence within bat populations ar...

Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbreaks with high mortality in primates. Whereas Marburg (MARV), Ebola Zaire (ZEBOV), and Ebola Sudan (SEBOV) viruses are pathogenic in humans, apes, and monkeys, Ebola Reston (REBOV) is pathogenic only in monkeys. Early immunosuppression may contribute to pathogenesis by facilitating viral replication. Lymphocyte depletion, intravasc...