INTRODUCTION Peripartum hemorrhage is one of the leading causes of maternal death worldwide (25%). METHODS Selective literature review, including international guidelines, for assessment of the causes and optimal management of this condition. RESULTS The major causes of hemorrhage are uterine atony, placenta previa, and abruptio placentae. The diagnosis of hemorrhage is suspected from its c...

BACKGROUND Placenta previa is known to be associated with previous caesarean deliveries, advanced maternal age, increasing parity, smoking, curettage and myomectomy. This study was carried out to compare the frequency of placenta previa, in women with previous caesareans versus those with normal vaginal deliveries. METHODS It was one year study conducted at the Department of Obstetrics and Gy...

OBJECTIVE The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined. DESIGN Omentin-1 levels were mea...

The placenta serves as the fetus' organ of gas exchange throughout intra-uterine life. While the dependence of fetal well-being on an intact maternal-placental unit has been recognized for centuries, it is only in the last several decades that research with fetal animals has begun to unravel the mechanisms by which it regulates blood supply and oxygen, as well as its role in the maternal-to-fet...

BACKGROUND Iron metabolism during pregnancy maintains fetal iron levels at the expense of the mother. The mechanism behind this regulation is still not clear despite recent advances. Here we examine the role of maternal and fetal Hfe, its downstream signaling molecule, hepcidin and dietary iron in the regulation of placental iron transfer. DESIGN AND METHODS Hfe wild-type, knockout and hetero...

The placenta is located between the maternal body and the fetus and is an organ indispensable for the fetus, with the combined functions of endocrine gland, lung, kidney, liver and digestive tract, but the mechanism of these functions is still obscure in many points. In the present study, electronmicroscopic observa tions were undertaken to study the mode of transition of substances through the...

the placental adhesive disorders such as placenta accreta and placenta percreta are the rare causes of serious obstetric hemorrhages. they are associated with high maternal morbidity and mortality. placenta percreta is usually diagnosed in the third trimester of pregnancy as a massive postpartum hemorrhage when an attempt to remove the placenta reveals lack of a cleavage plane. here we report a...

Introduction: Abruptio Placenta is a major cause of maternal morbidity and perinatal mortality globally and is of serious concern in the developing world. Materials and methods: A retrospective cohort study was designed and carried out between January and December 2015 in the Institute of Maternal and Child Health (IMCH) attached to GMC, Calicut. Results: We evaluated 140 cases of abruptio plac...

P ERIPARTUM hemorrhage is responsible for 150,000 maternal deaths worldwide each year. Although the risk of maternal death has decreased over the preceding century, there has recently been a concerning suggestion of an increase in the overall incidence of hemorrhage. Despite multiple advances in medical and surgical care, a steady rise in hemorrhage has been noted within the developed world. St...

UNLABELLED Placenta praevia/accreta is associated with significant maternal morbidity and mortality and is a common cause of obstetric hysterectomy. This paper describes posterior retrograde abdominal hysterectomy, a new surgical technique for caesarean hysterectomy, in 11 women with placenta percreta, increta or accreta There were no intraoperative or postoperative maternal complications, and ...