Although axonal extension to reconstruct spinal tracts should be effective for restoring function after spinal cord injury (SCI), chondroitin sulfate proteoglycan (CSPG) levels increase at spinal cord lesion sites, and inhibit axonal regrowth. In this study, we found that the water extract of roots of Sophora flavescens extended the axons of mouse cortical neurons, even on a CSPG-coated surface...

The current study aims to investigate the effects of matrine on the JAK-STAT signaling transduction pathways in bleomycin (BLM)-induced pulmonary fibrosis (PF) and to explore its action mechanism. A total of 72 male C57BL/6 mice were randomized into the control, model, and treatment groups. PF models were established by instilling BLM intratracheally. The treatment group was given daily matrine...

The asymmetric unit of the title compound, (C(15)H(25)N(2)O(2))[FeCl(4)], contains a tetra-chloridoferrate(III) anion and a oxymatrinium cation [oxymatrine is (4R,7aS,13aR,13bR,13cS)-dodeca-hydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide]. The conformation of oxymatrine is similar to that of matrine with one ring having a half-chair conformation, while the others hav...

A sensitive quantitative method for the determination of matrine alkaloids in human urine was developed based on hollow fiber liquid-phase microextraction (HF-LPME) combined with HPLC. The influence of the different factors on the HF-LPME efficiency including the pH and ion strength of the donar solution, the pH of the acceptor solution, stirring rate and extraction time were examined. The best...

The natural alkaloids extracted from Chinese herbal medicine have shown high medicinal value in vivo and vitro, such as bacteriostasis, anti-virus, anti-tumor anti-inflammation. This paper focuses on matrine reviews its action mechanism toxicological action. It is concluded that the prospect of very broad, but more basic research clinical trials are needed for comprehensive evaluation.