While it has been known for some time that chromatin is highly packaged, it has only recently been discovered that chromatin is attached to the nuclear matrix. It has also been recently shown that interphase chromosomes remain separate from one another in so called, “chromosome domains.” This author suggests a functional relationship between chromatin attachment to the nuclear matrix and chromo...

The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways are largely defined by the interactions between virus particles and their receptors at the cell surface. These interactions determine the mechanisms of virus attachment, uptake, intracellular trafficking, and, ult...

Page 3. Introduction Page 4. Methodology Page 6. Definition of Injury Page 6. Outline of Study Design Page 6. Participants Page 6. Questionnaire Page 6. Establishing face and content validity of questionnaire Page 7. Procedures Page 7. Statistical Analysis Page 7. Results Page 8. Injuries by Anatomic Region Page 8. Nature of Injury Page 9. Perceived Injury Cause Page 9. Treatment of Injury Page...

The immunoglobulin intragenic mu enhancer region acts as a locus control region that mediates transcriptional activation over large distances in germ line transformation assays. In transgenic mice, but not in transfected tissue culture cells, the activation of a variable region (V(H)) promoter by the mu enhancer is dependent on flanking nuclear matrix attachment regions (MARs). Here, we examine...

Hypocotyl elongation is extensively controlled by hormone signaling networks. In particular, auxin metabolism and signaling play key roles in light-dependent hypocotyl growth. The nuclear matrix facilitates organization of DNA within the nucleus, and dynamic interactions between nuclear matrix and DNA are related to gene regulation. Conserved scaffold/matrix attachment regions (S/MARs) are anch...

Nuclear matrix attachment regions (MARs) are thought to influence gene expression by anchoring active chromatin to the proteinaceous nuclear matrix. In this study, two plant DNA fragments with strong MAR activity were selected and tested for their effects on expression of a linked reporter gene in transgenic tobacco. One MAR was isolated from the 5' flanking region of a pea vicilin gene previou...

Survival of endothelial cells is critical for cellular processes such as angiogenesis. Cell attachment to extracellular matrix inhibits apoptosis in endothelial cells both in vitro and in vivo, but the molecular mechanisms underlying matrix-induced survival signals or detachment-induced apoptotic signals are unknown. We demonstrate here that matrix attachment is an efficient regulator of Fas-me...