Progressive memory loss is a symptom of many dangerous neurological diseases, such as Alzheimer's disease and forgetfulness. The goal this study was to see how well bioactive molecules worked in animal models amnesia caused by scopolamine. Ginger has lot Zingerone (Zn), which makes up about 9.25% the total amount. Gramine (Ga) nonterpenoid indole alkaloid that found plants like barley wheat. It...

Mitochondrial dysfunction is involved in aging and in neurodegenerative diseases and, therefore, pharmacological agents that alleviate mitochondrial dysfunction are expected to have neuroprotective effects. Promising in this respect is mitochondrial-targeted antioxidant plastoquinonyl-decyl-triphenylphosphonium (SkQ1). We investigated the effects of SkQ1 (250 nmol SkQ1/kg x day with food) on be...

The late postnatal period in rats is marked by numerous changes in perceptual and cognitive abilities. As such, age-related variation in cognitive test performance might result in part from disparate sensitivities to environmental factors. To better understand how testing conditions might interact with age, we assessed anxiety behavior on an elevated plus maze (EPM) in juvenile rats around 3 we...

The recent rapid development of electronic communication techniques is resulting in a marked increase in exposure of humans to electromagnetic fields (EMFs). This has raised public concerns about the health hazards of long-term environmental EMF exposure for fetuses and children. Some studies have suggested EMF exposure in children could induce nervous system disorders. However, gender-dependen...

BACKGROUND This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties of a plant Sterculia villosa leaves. Therefore, we tried to find out the methanolic extract from the leaves of Sterculia villosa leaves having any sedative activity or n...

Introduction: Searching for new compounds with anti-anxiety activity resulting from the combination of privileged scaffolds is a promising direction in medicinal chemistry and development drugs. Anxiolytic potential cytotoxic properties previously synthesized molecules, containing fragments 2,3-benzodiazepine 1,2,4-triazole – 6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-A][2,3]benzodiazepines und...

The Quechua term ayahuasca refers to a beverage obtained from decoctions of the liana Banisteriopsis caapi with leaves of Psychotria viridis. The ritualistic use of ayahuasca is becoming a global phenomenon, with some individuals using this beverage throughout life, including in old age. Cognitive impairment is a common manifestation during aging. There are conflicting reports on the ability of...

Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2h/day) and AM (400mg/kg) given by oral administration, in the AM group, ...

Despite being potent anxiolytic agents, benzodiazepines (BDZ) sometimes show reduced therapeutic efficacy in stressed rodents. However, the effectiveness of norepinephrine reuptake inhibitors (NRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) or other anxiolytic interventions, e.g., exercise, remained elusive. Here, we demonstrated that male rats subjected to restraint stress for 4 w...

The purpose of this study was to characterize the anxiolytic activity of an Aqueous extract prepared from the leaves of Mangifera indica L (AEMI) using an elevated plus maze (EPM) model in rat and staircase model in mice. In elevated plus maze (EPM) model, At dose of Mangifera indica (250mg/kg and 500mg/kg) treated group showed significant increase in the % time spent in open arm and no. of ent...