BACKGROUND Bronchodilator medications are central to the symptomatic management of chronic obstructive pulmonary disease (COPD). Metered-dose inhalers (MDIs) are the most commonly used devices to deliver treatment to patients with COPD and asthma, comprising approximately 70% of bronchodilator prescriptions. Proprietary porous-particle technology permits the formulation of long-acting muscarini...

The metered-dose inhalers (MDIs) currently available for inhaled Background: corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the ...

than one error simultaneously. We also studied the kind ofoutpatient contml, if any, devoted to these patients. As expected, the greatest percentage of errors was observed in the group of patients without any kind of medical advice (83%). However, practically the same proportion (79%) failed to use the MDIs properly despite the fact that they were under the supervision of medical outpatient car...

Modern local therapy for lung diseases is now largely based on pressurized metered-dose inhalers (MDIs). The research of alternatives to MDIs has recently accelerated, primarily due to environmental concerns related to the use of chlorofluorocarbon (CFC) propellants. The most recent and attractive solution to this problem is represented by the development of dry powder inhalers (DPIs), particul...

burden of COPD and that they address any demographic disparities in patients’ use of resources. These data would help clinicians and other health care professionals in developing disease-management programs that best suit a specific population. Bronchodilators are the mainstay for managing the symptoms of COPD. They may be prescribed on an as-needed basis at early stages of disease, but typical...

than one error simultaneously. We also studied the kind ofoutpatient contml, if any, devoted to these patients. As expected, the greatest percentage of errors was observed in the group of patients without any kind of medical advice (83%). However, practically the same proportion (79%) failed to use the MDIs properly despite the fact that they were under the supervision of medical outpatient car...

Therapeutic agents that inhibit a single target often cannot combat a multifactorial disease such as cancer. Thus, multi-target inhibitors (MTIs) are needed to circumvent complications such as the development of resistance. There are two predominant types of MTIs, (a) single drug inhibitor (SDIs) that affect multiple pathways simultaneously, and (b) combinatorial agents or multi-drug inhibitors...

Background: Long-acting muscarinic antagonist/long-acting β2-agonist combinations are recommended for patients whose chronic obstructive pulmonary disease (COPD) is not managed with monotherapy. We assessed the efficacy and safety of glycopyrrolate (GP)/formoterol fumarate (FF) fixed-dose combination delivered via a Co-SuspensionTM Delivery Technology-based metered dose inhaler (MDI) (GFF MDI)....

The metered-dose inhalers (MDIs) currently available for inhaled Background: corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the ...