Measles is a highly contagious disease causing an estimated 2.6 million deaths per year before a vaccine was developed. However, the attenuated measles vaccine has brought the disease under control. Vaccine-associated measles can occur in children and immunocompromised individuals. Little is known about the occurrence of vaccine-associated measles in healthy adults because preschool children us...

A number of slow neurological diseases occurring in an imals and in man appear to be associated with a long-term, chronic infection of the host by a virus or virall ike agent. Measles virus, or a var ian t of measles, has been shown to be the etiologic agent of the chronic and invar iab ly fatal human disease, subacute sclerosing panencephal i t is (SSPE). 1 In SSPE, the virus appears to produc...

Conclusion The absence of vaccination from multiple reasons explained the increased number of measles cases (with significant variations in county level). Eradication of measles has been proposed by many countries, e.g. USA, France for over 10 years without being actually realized. In 1993, the measles virus was more neurotropic (there were many cases of deadly encephalitis) compared to the vir...

Measles virus is a highly contagious virus causing acute and persistent diseases in man, the receptor of which is still not well characterized. We have isolated a monoclonal antibody (mAb), designated mAb 119, which specifically inhibits measles virus infection of susceptible cell lines in a dose-dependent manner. This antibody precipitates a protein with an apparent molecular mass of 75 kDa fr...

measles, mumps and rubella are viral infectious diseases that may result in serious complications. since the production of vaccines, the number of cases of these diseases has been dropped. nevertheless, these infectious diseases are still one of the major health problems in developing countries. in this study, in order to evaluate the protective responses against measles, mumps and rubella, the...

BACKGROUND The age at which passively acquired antibodies are lost is critical to determining the optimal age for measles vaccination. Little is known about the influence of human immunodeficiency virus type 1 (HIV-1) infection on levels of prevaccination antibodies to measles virus. METHODS Antibodies to measles virus were measured by plaque reduction neutralization assay in HIV-1-infected, ...

Following their initial isolation in cell culture of the virus in 1954, a succession of investigators under the mentorship of John F. Enders conducted the research, development, and initial clinical studies responsible for the licensure in 1963 of a successful live attenuated measles virus vaccine. Propagation of the virus successively in human kidney cells, human amnion cells, embryonated hens...

The measurement of functional measles virus-specific neutralizing antibodies is of considerable interest for vaccine-related research. In this study, we developed and standardized a simple, rapid, highly sensitive, and reproducible fluorescence-based plaque reduction microneutralization (PRMN) assay with visual and automated readout, using a recombinant measles virus engineered to express enhan...

Measles virus is a paramyxovirus which, like other members of the family such as respiratory syncytial virus, is a major cause of morbidity and mortality worldwide. The cell surface receptor for measles virus in humans is CD46, a complement cofactor. We report here the crystal structure at 3.1 A resolution of the measles virus-binding fragment of CD46. The structure reveals the architecture and...

Measles virus infection, a systemic rash illness commonly acquired in infancy and early childhood, is one of the most contagious infectious diseases in humans [1]. Measles is also an important cause of global morbidity and mortality, primarily among infants and children living in resource-limited settings [2]. Since the development of measles vaccines in the 1960s, intensive vaccination efforts...