We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH₂)₃CCH₃]Li with aryl halides occurred in the presence of Pd(OAc)₂/RuPhos complex in refluxin...

The Medical Entomology Branch (MEB) of Territory Health Services (THS) has confirmed the presence of established breeding populations of the exotic mosquito Culex gelidus in the towns of Katherine, Batchelor and Darwin in the Northern Territory (NT) of Australia. It is also probably present in Alice Springs. While there are no immediate public health risks, it adds to the number of pest and pot...

To understand the transport function of drugs across the canalicular membrane of hepatocytes, it would be important to measure concentrations in hepatocytes and bile. However, these concentration gradients are rarely provided. The aim of the study is then to measure these concentrations and define parameters to quantify the canalicular transport of drugs through the multiple resistance associat...

Mammalian cells produce many glycoproteins, i.e., proteins with covalently attached sugar chains. Recent advances in glycobiology have revealed the importance of sugar chains as biosignals for multi-cellular organisms including cell-cell communication, intracellular signaling, protein folding, and targeting of proteins within cells. The O-mannosyl linkage, which used to be considered specific t...

Top-coal caving technology is a productive and efficient method in modern mechanized coal mining, the study of coal-rock recognition is key to realizing automation in comprehensive mechanized coal mining. In this paper we propose a new discriminant analysis framework for coal-rock recognition. In the framework, a data acquisition model with vibration and acoustic signals is designed and the cav...

Protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) is an enzyme that transfers N-acetylglucosamine to O-mannose of glycoproteins. Mutations of the POMGnT1 gene cause muscle-eye-brain (MEB) disease. To obtain a better understanding of the pathogenesis of MEB disease, we mutated the POMGnT1 gene in mice using a targeting technique. The mutant muscle showed aberrant glyco...

Background: The present study aimed to quantify the relationship between body dissatisfaction and morbid exercise behaviour (MEB). Methods: electronic databases MEDLINE, PsycINFO, Web of Science, SciELO, Dissertations & Theses Global were searched from inception September 2020. Pooled effect sizes corrected for sampling errors (r+) computed using a bare-bones meta-analysis. robustness resul...

Eğitim olgusu dönemden döneme, her felsefeye göre farklılık göstermektedir. Bu tanımların hiçbiri yanlış değildir; fakat bu tanımlar toplumun geçirmiş olduğu dönüşümlere, toplumların ihtiyacına şekillenmektedir. çalışmada Türk düşün ve eğitim hayatında özgün bir yeri olan Ismayıl Hakkı Baltacıoğlu’nun anlayışı ile Millî Bakanlığı (MEB)’nın 2018 yılında yayımladığı 2023 Vizyonunda yer alan temel...

Standard SVM training has O(m3) time and O(m2) space complexities, where m is the training set size. It is thus computationally infeasible on very large data sets. By observing that practical SVM implementations only approximate the optimal solution by an iterative strategy, we scale up kernel methods by exploiting such “approximateness” in this paper. We first show that many kernel methods can...