Peripheral glucocorticoid receptors (GRs) play a significant role in the anti-inflammatory effects of glucocorticoids; however, the role of central GRs in nociceptive behaviors after peripheral nerve injury (neuropathic pain behaviors) remains unknown. Here we show that the development of neuropathic pain behaviors (thermal hyperalgesia and mechanical allodynia) induced by chronic constriction ...

It is well known that conservative mechanical systems exhibit local oscillatory behaviours due to their elastic and gravitational potentials, which completely characterise these periodic motions together with the inertial properties of system. The classification geometric characterisation are in an on-going secular debate, recently led so-called eigenmanifold theory. characterises nonlinear osc...

BACKGROUND Bone has the ability to adapt to mechanical usage or other biophysical stimuli in terms of its mass and architecture, indicating that a certain mechanism exists for monitoring mechanical usage and controlling the bone's adaptation behaviors. There are four zones describing different bone adaptation behaviors: the disuse, adaptation, overload, and pathologic overload zones. In differe...

It is difficult to establish a numerical model for a certain structure of electrospun nanofibrous mats, due to their high porosity and non-linear characteristics, that can fully consider these characteristics and describe their mechanical behaviors. In this paper, an analytical method of meso-mechanics was adopted to establish the tensile constitutive relationship between a single fiber and mat...