Mechanical stress plays a key role in the development of cartilage degradation in osteoarthritis (OA). Nevertheless, the role of long noncoding RNAs in mechanical stress-induced regulation of chondrocytes remains unclear. The aim of this study was to explore the function of mechanical stress-related long noncoding RNAs in cartilage. Tissue samples were collected from 50 patients and chondrocyte...

To repair articular cartilage defects in osteoarthritic patients with three-dimensional tissue engineered chondrocyte grafts, requires the formation of new cartilage with sufficient mechanical properties. The premise is that mechanical stimulation during the culturing process is necessary to reach this aim. Therefore, mechanical stimulation systems have been integrated in aseptic bioreactors fo...

Introduction Fibrillation of cartilage has been attributed to failure of the collagen network in its superficial layer [1]. Fatigue of the collagen fibrils, which can only carry tensile stresses, is thus seen as a contributor to the collagen network failure. Previous work on cartilage resistance to fatigue has been undertaken on specimens, which were loaded in the direction of the collagen in t...

Biomechanics plays a pivotal role in articular cartilage development, pathophysiology, and regeneration. During embryogenesis and cartilage maturation, mechanical stimuli promote chondrogenesis and limb formation. Mechanical loading, which has been characterized using computer modeling and in vivo studies, is crucial for maintaining the phenotype of cartilage. However, excessive or insufficient...

Articular cartilage is characterized by its poor capacity for self-repair. Once articular cartilage is injured and defected, it cannot be spontaneously repaired and finally develops osteoarthritis (OA). OA is a major leading cause of severe activity limitations and disability, resulting in worldwide socio-economical burden. At present, there is no established therapy for adequate repair of dama...

BACKGROUND A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage explants using a physiologically relevant explant model of joint injury combining cartilage mechanical compres...

Silica refractory bricks are used especially in the metallurgical industries, due to desirable properties such as high melting point, rigidity, and high temperatures strength. In this research, different amount of SiC were added to Silica refractory containing different binders such as Borax, Boric acid, Calcium nitride, Sodium tri poly phosphate, Sodium hexa meta phosphate (SHMP) and lime. Phy...

Excellent mechanical properties of carbon nanotubes (CNTs) make them outstanding candidate reinforcements to enhance mechanical properties of conventional composites. The glass/polyester composites are widely used in many industries and applications. Improving the mechanical properties of such composites with addition of CNTs can increase their applications. In this research, multi-walled carbo...

Recent developments in the area of hydrogels promise to greatly expand their scope of applications. Many applications require hydrogels to endure signicant mechanical loads in aggressive environments. Examples range from biomedical applications such as articial cartilage in tissue engineering, to engineering applications such as swellable packers in the oil industry, or articial nerves and m...

Silica refractory bricks are used especially in the metallurgical industries, due to desirable properties such as particularly their high melting point and their rigidity and strength at high temperatures. In this research, different amount of SiC were added to Silica refractory containing different binders such as Borax, Boric acid, Calcium nitride, Sodium tri poly phosphate, Sodium hexametaph...