Primary malignant mediastinal teratoma is a rare tumour previously regarded as inevitably fatal. In a series of eight male patients with a mean age of 24 years five remain alive and well. All patients showed raised serum concentrations of human chorionic gonadotrophin or alpha fetoprotein. The patients were treated with intermittent combination chemotherapy that included cisplatin. Six patients...

Teratomata arise, in order of frequency, in the ovaries, testes, anterior mediastinum, retroperitoneal region, presacral and coccygeal regions, pineal and other intracranial sites, neck, and abdominal viscera other than the gonads (Willis, 1951). Mediastinal teratomata rank third among all teratoid tumours and are the second most common mediastinal tumours (Inada and Nakano, 1958). The majority...

INTRODUCTION Teratomas of anterior mediastinum are rare tumors and are often slow growing, asymptomatic and detected incidentally on chest imaging. Results of surgical resection are very satisfactory. CASE PRESENTATION A 19-years old male presented with an asymptomatic cystic neck mass. X-ray and CT scan of chest and neck showed an extrathyroidal multi-septate, predominantly cystic neck mass,...

Germ cell tumors (GCTs) represent a well-recognized group of heterogeneous neoplasms with diverse clinical, histopathological, diagnostic, and prognostic characteristics. We present a rare case of a locally aggressive, chemotherapy-resistant immature mediastinal teratoma with a peculiar histological finding of a multilineage somatic-type malignant degeneration. A 21-year-old male patient presen...

Four cases of benign cystic mediastinal teratoma containing pancreatic tissue have been studied using immunohistochemical and morphometric techniques. The different pancreatic endocrine cell types were stained using antibodies to insulin, glucagon, somatostatin, and pancreatic polypeptide, and the volume density of each cell type was estimated by point counting. Sections from different regions ...

We present a case of metastatic testicular immature teratoma that was successfully treated despite resistance to standard chemotherapy and unsuccessful salvage surgery. At first, BEP (bleomycin, etoposide and cisplatin) treatment was performed but failed. The patient underwent incomplete retroperitoneal lymph node dissection. He was then referred to us. By the time of the referral lung and medi...