Omalizumab is an anti-human IgE humanized monoclonal antibody produced against CƐ3 domain of the Fc fragment of IgE molecule. Omalizumab suppresses the effector roles of IgE by preventing binding to high-affinity receptors (FcεR1) on allergy-related immune effector cells and blocking mast cell or basophil mediator release.4 Based on this mechanism of action, Omab also provides symptomatic relie...

We report the results of a genetic screen designed to identify transcriptional coregulators of yeast heat-shock factor (HSF). This sequence-specific activator is required to stimulate both basal and induced transcription; however, the identity of factors that collaborate with HSF in governing noninduced heat-shock gene expression is unknown. In an effort to identify these factors, we isolated s...

This paper presents a new intelligent mediators configuration approach which exploits high expressive description logics to represent metadata, and reasoning tasks in order to build more flexible mediation systems. A user specifies a needs expression in terms of (i) an interesting view over a given application domain, (ii) sources preferences and (iii) architectural requirements. A well-adapted...

let $d$ be an integral domain and $star$ a semistar operation stable and of finite type on it. we define the semistar dimension (inequality) formula and discover their relations with $star$-universally catenarian domains and $star$-stably strong s-domains. as an application, we give new characterizations of $star$-quasi-pr"{u}fer domains and um$t$ domains in terms of dimension ine...

The c-fos gene responds to extracellular stimuli and undergoes robust but transient transcriptional activation. Here we show that heterogeneous nuclear ribonucleoprotein R (hnRNP R) facilitates transcription reinitiation of the c-fos promoter in vitro in cooperation with Mediator. Consistently, hnRNP R interacts with the Scaffold components (Mediator, TBP, and TFIIH) as well as TFIIB, which rec...

Jasmonoyl-isoleucine (JA-Ile), the active form of the plant hormone jasmonate (JA), is sensed by the F-box protein CORONATINE INSENSITIVE 1 (COI1), a component of a functional Skp-Cullin-F-box E3 ubiquitin ligase complex. Sensing of JA-Ile by COI1 rapidly triggers genome-wide transcriptional changes that are largely regulated by the basic helix-loop-helix transcription factor MYC2. However, it ...

This paper presents a novel architectural solution for improving dependability of Web Services. This approach is based on the concepts from the emerging resilienceexplicit computing combined with the traditional fault-tolerance techniques such as recovery blocks and N-version programming applied in the context of the serviceoriented architecture. We propose a distributed solution called WS-Medi...