BACKGROUND Although clinical trial results suggest that meloxicam has less gastrointestinal toxicity than most other non-steroidal anti-inflammatory drugs (NSAIDs), in practice it has been associated with a large number of yellow card reports of gastrointestinal complications. AIMS To estimate whether meloxicam and the coxibs, rofecoxib and celecoxib, have been channelled towards high risk pa...

BACKGROUND The benefit of pre and post-operative administration of non-steroidal anti-inflammatory drugs for the relief of post-operative pain and control of inflammation in horses following orthopaedic surgery has not been previously investigated in controlled clinical field trials, and the utility of such treatment is a matter of ongoing dispute. Recently the utility of post-operative pain ma...

BACKGROUND Lines of evidence have indicated that cyclooxygenase 2 plays a role in the pathophysiology of neuropathic pain. However, the site and mechanism of its action are still unclear. Spinal glia has also been reported to mediate pathologic pain states. The authors evaluated the effect of continuous intrathecal or systemic cyclooxygenase-2 inhibitor on the development and maintenance of neu...

HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------------WARNINGS AND PRECAUTIONS-----------------------­ These highlights do not include all the information needed to use MOBIC  Serious and potentially fatal cardiovascular (CV) thrombotic events, safely and effectively. See full prescribing information for MOBIC. myocardial infarction, and stroke. Patients with known CV disease/risk facto...

group. There were no significant differences in the 24-hr changes in GFR or serum cortisol level, This study showed that perioperative administration of meloxicam reduced unfayorable postoperative changes in the cardiovascular system without influencing renal function. KEy woRDs: canine, cardiovascular parameters, meloxicam, preemptive analgesia, telemetry system, J. vlet, Med, Sci. 69(9): 939-...

AIM To investigate the effect of the administration of a single dose of meloxicam pre-emptively on postoperative pain management in patients who underwent inguinal hernia repair under local anaesthesia. SUBJECTS AND METHOD Fifty patients who underwent inguinal hernia repair under local anaesthesia during the period November 2005 to May 2006 were recruited into the study prospectively. The pat...

A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantification of Meloxicam in bulk and tablet dosage form with greater precision and accuracy. Separation was achieved on Develosil ODS HG-5 RP C18, (15 cm × 4.6 mm i.d. 5 μm) column in isocratic mode with mobile phase consisting of acetonitrile: phosphate buffer(pH 3.4...

BACKGROUND Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for ...

BACKGROUND Atherosclerosis is a complex vascular inflammatory disease. In the last decade it was suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) and in particular inhibition of cyclooxygenase (COX)-2 are associated with an increase in cardiovascular morbidity and mortality. Aspirin is known to reduce the incidence and mortality from ischemic heart disease and is a mainstay in the p...

Diclofenac Sodium, a Non-steroidal anti-Inflammatory drug (NSAID) was banned for veterinary use in Pakistan, India and Nepal in 2005-06 due to its relay toxicity associated with catastrophic decline in the populations of vulture in South Asia. The main aim of the present research was to study pharmacokinetics of meloxicam in goats under local conditions. Meloxicam is another NSAID, reported as ...