OBJECTIVES In this study the efficacy of doripenem, a new broad-spectrum carbapenem, was tested against an Escherichia coli strain and a Klebsiella pneumoniae strain in an experimental animal model. The comparator was cefepime monotherapy. METHODS The rabbit meningitis model was used in this study and the penetration of doripenem through uninflamed and inflamed meninges was determined. RESU...

During 1 year, experimentally naïve C57BL/6NCrl weanlings born to timed-pregnant dams from a single vendor demonstrated markedly increased mortality associated with runting, abnormal gait, and decreased activity. Gram-positive, aerobic, α-hemolytic, coccoid bacteria were isolated from the meninges (n = 16), blood (n = 1), and kidneys (n = 1) of clinically affected weanlings (n = 15); from the u...

Rabbit leucocytes, injected into the basal meninges of dogs, in doses from 0.7 to one cubic centimeter apparently invariably cause death. Horse leucocytes, injected in the same amounts, cause death in about 25 per cent. of the dogs. . The injection of foreign leucocytes into the meninges of monkeys causes few if any symptoms. The injection of from one to three cubic centimeters of horse leucocy...

An exceptional case of intracranial plasma cell granuloma, located in the right frontoparietal convexity in a 16-year-old boy is reported. Reports of these rare inflammatory lesions locate them primarily in the lungs and in other regions of the body, and only exceptionally in the nervous system; indeed, only three intracranial cases and one other arising from the spinal meninges have been repor...

As meninges são estruturas membranosas que têm como principal função o revestimento do cérebro e da medula espinhal. São divididas em 3 (dura-máter, aracnoide pia-máter). A meningite é uma síndrome caracterizada pela inflamação das meninges, devido a um processo infeccioso ou até mesmo de origem química/inflamatória, podendo levar quadros neurológicos leves graves ao óbito. Os agentes etiológic...

Evidence for the presumed linkage between the enigmatic rodlet cells of fish and exposure to helminths is anecdotal and indirect. We evaluated the proliferation and development of rodlet cells in the optic lobes of fathead minnows exposed to cercariae of Ornithodiplostomum ptychocheilus. Mean rodlet cell densities (ca. 10/mm(2)) in the optic lobes were similar between unexposed controls and min...

PURPOSE To evaluate the effect of ketamine S (+) 5% with no preservatives and administered as a subarachnoid single puncture on the spinal cord and meninges of rabbits. METHODS Twenty young adult female rabbits, each weighing 3500-5000 g and having a spine length between 34 and 38 cm, were divided by lot into two groups (G): 0.9% saline in G1 and ketamine S (+) 5% in G2, by volume of 5 μg per...

Meninges, the connective tissue of the vertebrate central nervous system (CNS), have not been recognized in invertebrates. We describe the ultrastructure of the adult brain, antennules, and cord in five marine copepods: Calanus finmarchicus, Gaussia princeps, Bestiolina similis, Labidocera madurae, and Euchaeta rimana. In all of these locations we identified cell types with characteristics of t...