BACKGROUND & OBJECTIVES Typhoid fever caused by Salmonella Typhi continues to be a major health problem in spite of the use of antibiotics and the development of newer antibacterial drugs. Inability to make an early laboratory diagnosis and resort to empirical therapy, often lead to increased morbidity and mortality in cases of typhoid fever. This study was aimed to optimize a nested PCR for ea...

This is a case report of a 12-year-old returned traveler with typhoid and scrub typhus coinfection. The diagnosis of typhoid was made early with blood cultures and Widal Weil Felix serology. Persistent fever despite appropriate antibiotics for typhoid fever prompted a search for concomitant infection, which led to the diagnosis of scrub typhus confirmed by Orientia tsutsugamushi serology. The p...

BACKGROUND In developed countries, typhoid fever is a travel-associated disease that is often overlooked. However, as standard blood and stool culture methods have relatively low sensitivity, diagnosis depends heavily on clinical signs and symptoms and on a high level of suspicion. METHODS Reported here is the case of an 18-year-old male who presented with fever and acute scrotal ulcers and w...

Typhoid fever is an acute systemic infection caused by the bacterium Salmonella enterica serovar Typhi. Salmonella enterica serovars Paratyphi A, B, and C cause the clinically similar condition, paratyphoid fever. Typhoid and paratyphoid fevers are collectively referred to as enteric fevers. In most endemic areas, approximately 90% of enteric fever is typhoid. Typhoid is transmitted by the feca...

The diagnostic value of an acute-phase single-tube Widal test for suspected typhoid fever was evaluated with 2,000 Vietnamese patients admitted to an infectious disease referral hospital between 1993 and 1998. Test patients had suspected typhoid fever and a blood culture positive for Salmonella typhi (n= 1,400) or Salmonella paratyphi A (n = 45). Control patients had a febrile illness for which...

We have previously shown that an assay based on detection of anti-Salmonella enterica serotype Typhi antibodies in supernatant of lymphocytes harvested from patients presenting with typhoid fever (antibody in lymphocyte supernatant [ALS] assay) can identify 100% of patients with blood culture-confirmed typhoid fever in Bangladesh. In order to define immunodominant proteins within the S. Typhi m...

Salmonellosis is one of the commonest endemic diseases in Tropical Africa. Furthermore, typhoid fever is a disease that is unique to man with no other animal species acquiring an illness similar to man even after oral ingestion of the live jrganisms (Homick et al., 1970). Typhoid fever has a myriad of complications. Typhoid colitis is distinctly uncommon judging from the paucity of reports in t...

Background: To study the reliability of a single Widal test and to find out the diagnostic significance of ‘O’ and ‘H’ agglutinin titre in the diagnosis of typhoid fever. Methods: Community-based case-control study conducted from Jan 2001 to June 2007. The blood samples were collected from the medical and out door department of Sir Ganga Ram Hospitals, Lahore. The diagnostic value of an acute p...

Typhoid fever is a systemic prolonged febrile illness caused by a bacteria Salmonella typhi. The disease is transmitted through ingestion of food or water contaminated with faeces or urine of infected persons. Acute typhoid fever is characterized by prolonged fever, disturbances of bowel functions (constipation or diarrhoea), headache, malaise and anorexia. Cough is common in the early stage of...